Protein Alignment eIF3c and Eif3c

DIOPT Version :10

• Sequence 1: NP_611242.1
• Gene: eIF3c / 37005
• FlyBaseID: FBgn0034258
• Length: 910
• Species: Drosophila melanogaster
• Sequence 2: NP_001094132.1
• Gene: Eif3c / 293484
• RGDID: 1308871
• Length: 911
• Species: Rattus norvegicus
• Alignment Length: 937
• Identity: 479/937 - (51%)
• Similarity: 636/937 - (67%)
• Gaps: 65/937 - (6%)

  Fly     1 MSRFFANGSESESESS---EEEIQ---ATNFNKASAFQFSDDEEEVKRVVRSTKEKRYENLTSII 59
            |||||..||:||||||   ||.:.   :.|:.| .....|:|||:.||||||.|:||:|.||::|
  Rat     1 MSRFFTTGSDSESESSLSGEELVTKPVSGNYGK-QPLLLSEDEEDTKRVVRSAKDKRFEELTNLI 64

  Fly    60 KTIRNHKKIKDIPNTLSSFEDLTRAYQKALPVISKEENGITPRFYIRCLAELEDFINEVWEDREG 124
            :||||..||:|:...|..||.|.:||.||..::.||  |: ||||:|.||:|||::||:|||:||
  Rat    65 RTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKE--GV-PRFYVRILADLEDYLNELWEDKEG 126

  Fly   125 RKNLSKNNSKSLGTLRQKVRKYIKDFEDDLSRFREAPDQESEAEDEVVALESDGGDAGDDSDAGV 189
            :|.::|||:|:|.|||||:|||.:|||..::.:::.|:|.::.:.|....:|:|....|:.|.||
  Rat   127 KKKMNKNNAKALSTLRQKIRKYNRDFESHITNYKQNPEQSADEDAEKNEEDSEGSSDEDEDDDGV 191

  Fly   190 KPTEAVPKAVKSAPA-----KAAPADDDDSDDSID--WD-SDSESETESSDDENQYQNMRERFLK 246
            ..|..:.|...|:..     |....||:||:||.|  || |.:.|:::|.::|.:...:..:|||
  Rat   192 SGTAFLKKKPDSSGESRKFHKKMEDDDEDSEDSEDEEWDTSSTSSDSDSEEEEGKQTVLASKFLK 256

  Fly   247 R--TTEKEEK-DDDKRKDKRKEQKTKIRKR----AEDDEDGEWETVVKG--HVVEKPKMFEKDAE 302
            :  |||:::| .:.||:||.|::..:..||    .||:|.||||.|..|  .|.||||||.|..|
  Rat   257 KAPTTEEDKKAAEKKREDKAKKKHDRKSKRMDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTE 321

  Fly   303 IDVPLVLAKLLEIMSARGKKRTDRRLQIDLLFELRDISDQHNLGTAVSVKIHFNIISAIYDYNQK 367
            |...:|:.||.||:..||||.|||..||:||..|..|:.::|||..|.|||.||||:::||||..
  Rat   322 ITHAVVIKKLNEILQVRGKKGTDRATQIELLQLLVQIASENNLGVGVIVKIKFNIIASLYDYNPN 386

  Fly   368 ISEPMKLEHWALLLEVMQSMMKLLLANADIIMSESVAEEHEEYAT--SPFYVRGCPLAAVERLDD 430
            ::..||.|.|.:.|:.:..:|..|:|:::|.:.|::.||.|....  .|..||||.|..|||:|:
  Rat   387 LATYMKPEMWQMCLDCINELMDTLVAHSNIFVGENILEESENLHNFDQPLRVRGCILTLVERMDE 451

  Fly   431 EFVKLLKECDPHSNDYVSRLKDEVNVVKTIELVLQYFERSGTNNERCRIYLRKIEHLYYKFD--- 492
            ||.|:::..||||.:||..||||..|...||.|.:|.|..||..|.|:||||:|.|.|||||
  Rat   452 EFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEICQIYLRRILHTYYKFDYKA 516

  Fly   493 -------PE-VLKKKRGELPATTSTSVDVMDKLCKFIYAKDDTDRIRTRAILAHIYHHAMHDNWF 549
                   || ..|.::.:.......|..:|::|||:|||||.||||||.|||.||||||:|..|:
  Rat   517 HQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHSRWY 581

  Fly   550 QARDLVLMSHLQDNIDAADPATRILYNRMMANLGLCAFRQGNVKDAHHCLVDLMVTGKPKELLAQ 614
            |||||:|||||||||..|||..:|||||.|..||:||||||..||||:.|:|:..:|:.||||.|
  Rat   582 QARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQ 646

  Fly   615 GLLPQRQHERSAEQEKIEKQRQMPFHMHINLELLECVYLVSAMLLEIPYIAAHEFDARRRMISKT 679
            |||.:...||:.||||:|::||:|||:||||||||||||||||||||||:||||.|||||||||.
  Rat   647 GLLLRSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQ 711

  Fly   680 FYQQLRSSERQSLVGPPESMREHVVAAAKAMRCGNWQACANFIVNKKMNTKVWDLFYESDRVREM 744
            |:.|||..|||.|:|||||||||||||:|||:.|:|:.|.:||:|:|||.||||||.|:|:||.|
  Rat   712 FHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTM 776

  Fly   745 LTKFIKEESLRTYLFTYSNVYTSISIPSLAQMYELPVPKVHSIISKMIINEELMASLDDPSETVG 809
            |.:.|:||||||||||||:||.|||:.:|:.|:||.:|.|||||||||||||||||||.|::||.
  Rat   777 LVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQTVV 841

  Fly   810 MHRSEPSRLQALAMQFVDKVTNLVDVNEKVFDMKQGNFFQRGNMGNRGDRGYNRNQNNQGGNWLG 874
            |||:||:..|.||:|..:|:.:||:.||:|||.|||.:                     ||.:
  Rat   842 MHRTEPTAQQNLALQLAEKLGSLVENNERVFDHKQGTY---------------------GGYF-- 883

  Fly   875 QRRDRNNRNRNQRGHHKNNQDRQQQQQ 901
              ||:.:..|...|:.:....||||.|
  Rat   884 --RDQKDGYRKNEGYMRRGGYRQQQSQ 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF3c	NP_611242.1	eIF-3c_N	24..671	CDD:428482	334/676 (49%)
		PINT	744..823	CDD:214509	54/78 (69%)
Eif3c	NP_001094132.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		20/43 (47%)
		eIF-3c_N	29..703	CDD:428482	334/677 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..299		44/144 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	520..540		3/19 (16%)
		PINT	776..864	CDD:214509	57/87 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	883..911		9/30 (30%)