DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF3c and eif-3.C

DIOPT Version :9

Sequence 1:	NP_001286545.1	Gene:	eIF3c / 37005	FlyBaseID:	FBgn0034258	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_492638.1	Gene:	eif-3.C / 172858	WormBaseID:	WBGene00001226	Length:	898	Species:	Caenorhabditis elegans

Alignment Length:	932	Identity:	395/932 - (42%)
Similarity:	586/932 - (62%)	Gaps:	84/932 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRFF--ANGSESESESSEEEIQATNFNKASAFQFSDD-------EEEVKRVVRSTKEKRYENLT 56
            |||||  ...|:|::.|||:|::....||::  :|.||       ||:.|||||:.|:|:::.|.
Worm     1 MSRFFHAKEDSDSDTSSSEDEVEDQKVNKSA--KFRDDLDFMAGPEEDEKRVVRAQKDKKFDELK 63

  Fly    57 SIIKTIRNHKKIKDIPNTLSSFEDLTRAYQKALPVISKEENGITPRFYIRCLAELEDFINEVWED 121
            .|||..|:.|..||:...|:.|:.|.:||.|:..|..: :|...||||||.|.|:||::|::|:|
Worm    64 GIIKQNRDAKSNKDLNRLLTGFDSLAKAYDKSKTVFQR-QNVANPRFYIRSLVEIEDYVNKLWDD 127

  Fly   122 REGRKNLSKNNSKSLGTLRQKVRKYIKD--FEDDLSRFREAPDQE--SEAEDEVVALESDGGDAG 182
            ::.:..|||||:|:|..||||::|||||  .:|.::.:|..||::  ...|||
Worm   128 KDAKSALSKNNAKALPPLRQKLKKYIKDQQLQDLVTDYRVNPDEDGYETPEDE------------ 180

  Fly   183 DDSDAGVKPTEAVPKAVKSAPAKAAPAD---DDDSDDSIDWDSDSESETESSDDEN---QYQNMR 241
            ||.|.|........|:......|||.:|   |.|.|||.:|  .||.|:.|||||:   :.:.:|
Worm   181 DDDDFGEVSESKAEKSPGKPSEKAAVSDSDSDSDDDDSSNW--SSEPESNSSDDEDSVTKMEQLR 243

  Fly   242 ERFLKRTTEKEEKDDDKRKDKRKEQKTKIRKRAEDDEDGEWETVVKGHVVEKPKM-FEKDAEIDV 305
            ..|||:....|.|||.|.|.||   ..::::..|:|:|.:|..|.:    ||..: |:...|:..
Worm   244 RYFLKKEFRVESKDDKKEKKKR---VIRVKEAVEEDDDADWTPVNR----EKSVVHFDPKEEVTH 301

  Fly   306 PLVLAKLLEIMSARGKKRTDRRLQIDLLFELRDISDQHNLGTAVSVKIHFNIISAIYDYNQKISE 370
            .:::.||.|:||||||:.|||...:..|.:|.::|::..||..::|||.|.||||:::.|.|||:
Worm   302 DVMIKKLNEVMSARGKRTTDRNQHVANLRKLLEVSEEKELGLGINVKISFCIISALFELNAKISD 366

  Fly   371 PMKLEHWALLLEVMQSMMKLLLANADIIMSESVAEEHEEYA--TSPFYVRGCPLAAVERLDDEFV 433
            .|:.|.:...|:.:.|::.||:....:.:|.:.|||.|...  |..:.::|..|.||:|||.|..
Worm   367 HMEYETFMTTLQTVNSLLDLLIGTDRVKLSVTYAEEDENLKDDTQEYRIQGSILIAVQRLDGELA 431

  Fly   434 KLLKECDPHSNDYVSRLKDEVNVVKTIELVLQYFE---RSG--TNNERCRIYLRKIEHLYYKFDP 493
            |:|:..|.|||||:.:||.|.::...||...:|.|   .||  ..:|.|::|:.:|||.|||:..
Worm   432 KILQNADCHSNDYIEKLKAEKDMCSLIEKAEKYVELRNDSGIFDKHEVCKVYMMRIEHAYYKYQD 496

  Fly   494 EVLKKKRGELPATTSTSVDVMDKLCKFIYAKDDTDRIRTRAILAHIYHHAMHDNWFQARDLVLMS 558
            : .::..|:|          ||.||..||..||..|:|.||:|.|:|:.|:||.|.:||||:|||
Worm   497 Q-NEEDAGKL----------MDYLCNKIYTLDDEKRLRQRAMLCHVYYLAVHDKWHRARDLLLMS 550

  Fly   559 HLQDNIDAADPATRILYNRMMANLGLCAFRQGNVKDAHHCLVDLMVTGKPKELLAQGLLPQRQHE 623
            |:|..:|.:|..|:|||||.:..|||||||.|.:::||..|.::..|.:.||||||. :..||||
Worm   551 HMQAIVDHSDVDTQILYNRTICQLGLCAFRHGFIREAHQGLSEIQNTQRAKELLAQA-VGTRQHE 614

  Fly   624 RSAEQEKIEKQRQMPFHMHINLELLECVYLVSAMLLEIPYIAAHEFDARRRMISKTFYQQLRSSE 688
            ::||||||::.||:|:|||||:||:|||||:.:||||||::|:.||:.||||:|::|:.||:.||
Worm   615 KTAEQEKIDRSRQVPYHMHINVELMECVYLICSMLLEIPHMASCEFEMRRRMLSRSFHYQLKQSE 679

  Fly   689 RQSLVGPPESMREHVVAAAKAMRCGNWQACANFIVNKKMNTKVWDLFYESDRVREMLTKFIKEES 753
            :.||.||||:.|||||||:|||..|:|:.|.::|||.|||.|||:||:.::.|:.|:.:.|:|||
Worm   680 KASLTGPPENTREHVVAASKAMLNGDWKKCQDYIVNDKMNQKVWNLFHNAETVKGMVVRRIQEES 744

  Fly   754 LRTYLFTYSNVYTSISIPSLAQMYELPVPKVHSIISKMIINEELMASLDDPSETVGMHRSEPSRL 818
            |||||.|||.||.::|:..||.::||....||||||||||.|||.|:||:|::.:.|||.|||||
Worm   745 LRTYLLTYSTVYATVSLKKLADLFELSKKDVHSIISKMIIQEELSATLDEPTDCLIMHRVEPSRL 809

  Fly   819 QALAMQFVDKVTNLVDVNEKVFDMK--------QGNFF----------QRGNMGNRGDRGYNRNQ 865
            |.||:...||:..|.:.||::.:.:        .|::|          |:|:.|.:|:|...:.|
Worm   810 QMLALNLSDKLQTLAENNEQILEPRTGRGGYQGPGSWFPGRNERQGDKQKGSGGYQGERRGGQGQ 874

  Fly   866 NNQGGNW---LGQRRDRNNRNR 884
            :.:.|||   .||:|....:.|
Worm   875 DGKRGNWGSQGGQQRRHPQKPR 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3c	NP_001286545.1	eIF-3c_N	24..671	CDD:283193	275/671 (41%)
eIF3c	NP_001286545.1	PAM	744..823	CDD:214803	47/78 (60%)
eif-3.C	NP_492638.1	eIF-3c_N	31..662	CDD:283193	273/666 (41%)
		PAM	735..823	CDD:214803	50/87 (57%)
		DUF3628	833..>897	CDD:289100	15/64 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160121
Domainoid	1	1.000	469	1.000	Domainoid score	I215
eggNOG	1	0.900	-	-		E1_KOG1076
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2781
Inparanoid	1	1.050	690	1.000	Inparanoid score	I358
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54519
OrthoDB	1	1.010	-	-		D120738at33208
OrthoFinder	1	1.000	-	-		FOG0003671
OrthoInspector	1	1.000	-	-		oto20554
orthoMCL	1	0.900	-	-		OOG6_101999
Panther	1	1.100	-	-	LDO	PTHR13937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R378
SonicParanoid	1	1.000	-	-		X2545
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840