Protein Alignment eIF3c and eIF3c

DIOPT Version :10

• Sequence 1: NP_611242.1
• Gene: eIF3c / 37005
• FlyBaseID: FBgn0034258
• Length: 910
• Species: Drosophila melanogaster
• Sequence 2: XP_318103.3
• Gene: eIF3c / 1278503
• VectorBaseID: AGAMI1_005214
• Length: 955
• Species: Anopheles gambiae
• Alignment Length: 933
• Identity: 606/933 - (64%)
• Similarity: 737/933 - (78%)
• Gaps: 42/933 - (4%)

  Fly     1 MSRFFANGSESESESSEEEIQATNFNKASAFQFSDDEEEVKRVVRSTKEKRYENLTSIIKTIRNH 65
            ||||||.||:|:|:||.:. :.....:.:.|.|||:||:|||||||.||||||:|::|||:||||
Mosquito     1 MSRFFAGGSDSDSDSSSDS-EPVIRQQVAQFTFSDEEEDVKRVVRSKKEKRYEDLSNIIKSIRNH 64

  Fly    66 KKIKDIPNTLSSFEDLTRAYQKALPVISKEENGITPRFYIRCLAELEDFINEVWEDREGRKNLSK 130
            |||||:.:.|:|||:..|||.|||||:.|||||:|||..:|.|||||||:||.|:|:|.||||||
Mosquito    65 KKIKDMSSVLTSFEEFMRAYTKALPVVMKEENGVTPRIVVRALAELEDFVNESWDDKESRKNLSK 129

  Fly   131 NNSKSLGTLRQKVRKYIKDFEDDLSRFREAPDQESEAEDEVVALESDGGDAGDDSDAGVKPTEAV 195
            ||:|:|||||||.||||||||.|:.|||.||:..:|.|::    :....:.|.|.:......:..
Mosquito   130 NNNKALGTLRQKFRKYIKDFESDMKRFRAAPEDFAEEEED----DEREDEKGSDEEEEKVVVQVE 190

  Fly   196 PKAV--KSAPAKAAPADDDDSDDSIDWDSDSESETESSDDENQYQNMRERFLKRTTEKEEK---- 254
            ||||  |..|.||.|.......||.||.|||:|::.|||::.:|.::|:||||:..:..|:
Mosquito   191 PKAVSFKKEPEKAKPVKPVADSDSSDWGSDSDSDSTSSDEDAKYTSIRDRFLKKPEKGTEEIASA 255

  Fly   255 ------DDDKRKDKRKEQKTKIRKRA-----------EDDEDGEWETV--VKGHVVEKPKMFEKD 300
                  ||..:|:|:|:....:.|:.           |::|:| |:.|  .:....|:||||.||
Mosquito   256 PSGVSGDDAFKKEKKKKTGEALSKKKKPKQDEMFDENEEEEEG-WKVVNGTRSGASEQPKMFAKD 319

  Fly   301 AEIDVPLVLAKLLEIMSARGKKRTDRRLQIDLLFELRDISDQHNLGTAVSVKIHFNIISAIYDYN 365
            ||||..||:.||.|:|:|||||||||::||:.|.|||.:::.:|||.||:|||.|||:|||:|||
Mosquito   320 AEIDTKLVVNKLNEVMAARGKKRTDRKMQIEFLRELRTVAETNNLGPAVAVKIRFNIVSAIFDYN 384

  Fly   366 QKISEPMKLEHWALLLEVMQSMMKLLLANADIIMSESVAEEHEEYATSPFYVRGCPLAAVERLDD 430
            .|:|..||||||:.|||.:|.::|||||:.|:.:|||:.:|:|||.|:||.:|||.|.|||||||
Mosquito   385 PKVSGAMKLEHWSKLLEEIQELLKLLLAHEDVHLSESILDEYEEYDTAPFKIRGCMLTAVERLDD 449

  Fly   431 EFVKLLKECDPHSNDYVSRLKDEVNVVKTIELVLQYFERSGTNNERCRIYLRKIEHLYYKFDPEV 495
            ||.|||||||||||:||.||||||.|...||.|:.|.||.|...|.||||||||:||||||||:|
Mosquito   450 EFTKLLKECDPHSNEYVDRLKDEVPVTNIIEQVVTYVERLGNEMEICRIYLRKIDHLYYKFDPDV 514

  Fly   496 LKKKRGELPATTSTSVDVMDKLCKFIYAKDDTDRIRTRAILAHIYHHAMHDNWFQARDLVLMSHL 560
            |||::|:|||.|.|||:.|||||::|||||.|||:||||||:||:|||:||||||||||||||||
Mosquito   515 LKKRKGQLPANTITSVEEMDKLCRYIYAKDQTDRLRTRAILSHIFHHALHDNWFQARDLVLMSHL 579

  Fly   561 QDNIDAADPATRILYNRMMANLGLCAFRQGNVKDAHHCLVDLMVTGKPKELLAQGLLPQRQHERS 625
            |:.|..:||||:||||||||||||||||.||:||||.||||||:||||||||||||:||||||||
Mosquito   580 QETIHHSDPATQILYNRMMANLGLCAFRHGNIKDAHLCLVDLMMTGKPKELLAQGLVPQRQHERS 644

  Fly   626 AEQEKIEKQRQMPFHMHINLELLECVYLVSAMLLEIPYIAAHEFDARRRMISKTFYQQLRSSERQ 690
            .|||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||
Mosquito   645 LEQEKIEKQRQMPFHMHINLELLECVYLVSAMLLEIPYMAAHEFDARRRMISKTFYQQLRSSERQ 709

  Fly   691 SLVGPPESMREHVVAAAKAMRCGNWQACANFIVNKKMNTKVWDLFYESDRVREMLTKFIKEESLR 755
            |||||||||||||||||||||.|:|.||||||||||||.||||||||::|||||:.|||||||||
Mosquito   710 SLVGPPESMREHVVAAAKAMRHGDWNACANFIVNKKMNVKVWDLFYEANRVREMMIKFIKEESLR 774

  Fly   756 TYLFTYSNVYTSISIPSLAQMYELPVPKVHSIISKMIINEELMASLDDPSETVGMHRSEPSRLQA 820
            |||||||||:.|||:|.||.|::||..||||:|||||||||||||||||:||:.|||||||||||
Mosquito   775 TYLFTYSNVFASISVPHLADMFKLPKSKVHSLISKMIINEELMASLDDPTETIVMHRSEPSRLQA 839

  Fly   821 LAMQFVDKVTNLVDVNEKVFDMKQGNFFQRGNMGNRGDRGYNRN-QN----NQGGNWLGQRRDRN 880
            |:||..||||||||.||::|:||||||||||     |::||||: ||    ||..||...|| ::
Mosquito   840 LSMQLADKVTNLVDANERIFEMKQGNFFQRG-----GNQGYNRDRQNYRNQNQNQNWNNNRR-QD 898

  Fly   881 NRNRNQRGHHKNNQDRQQQQQQQ 903
            ||||..||:....:.|:|::..:
Mosquito   899 NRNRGNRGNQNRGEGREQREHHR 921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF3c	NP_611242.1	eIF-3c_N	24..671	CDD:428482	419/671 (62%)
		PINT	744..823	CDD:214509	63/78 (81%)
eIF3c	XP_318103.3	eIF-3c_N	30..690	CDD:428482	438/684 (64%)
		PINT	765..851	CDD:214509	65/85 (76%)