Protein Alignment CCHa1-R and KISS1R

DIOPT Version :10

• Sequence 1: NP_611241.2
• Gene: CCHa1-R / 37004
• FlyBaseID: FBgn0050106
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: XP_047295501.1
• Gene: KISS1R / 84634
• HGNCID: 4510
• Length: 459
• Species: Homo sapiens
• Alignment Length: 414
• Identity: 106/414 - (25%)
• Similarity: 160/414 - (38%)
• Gaps: 106/414 - (25%)

  Fly    73 VPYGRRPETYIVPILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVIITTVPL 137
            ||..|..:.::||:.||.:.::|::||..:|.|....:.||.|.|.||.:||..|:..::..||.
Human    34 VPSPRAVDAWLVPLFFAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPF 98

  Fly   138 ASTVYTVEYWPYGSFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRATRM 202
            .:.:|.:..|..|.|:|....:::.||:..:..||||:|.||::..|.|||..|     ||..|:
Human    99 TALLYPLPGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALH-----RRTPRL 158

  Fly   203 TLATAVSIWLLAILCGLPALIGSNLKHLGINEKSIVICYPYPEEW------GINYAKSMVLLHFL 261
            .||.::|||:.:.....|.|....|.             |.|..:      .....::..|.:.|
Human   159 ALAVSLSIWVGSAAVSAPVLALHRLS-------------PGPRAYCSEAFPSRALERAFALYNLL 210

  Fly   262 VYYAIPLVVIAVFYVLIALHLMYSASVPGEIQ--------------------------------- 293
            ..|.:||:.....|..:..||...|..|....
Human   211 ALYLLPLLATCACYAAMLRHLGRVAVRPAPADSALQVRGVGGRTARLGGRGGTVVGGAGGGICAG 275

  Fly   294 --------GAVR---------------------QVRARR------KVAVTVLAFVVIFGICFLPY 323
                    ||||                     ||.|.|      ||:..|.|.|::|..|:.|.
Human   276 RDSPRGPGGAVRGDELSRAPAFRLTTFTAPPQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPI 340

  Fly   324 HVFFLWFYFWPTAQDDYNAFWH-------VLRIVAYCMSFANSCANPVALYFVSGAFRKHFNRYL 381
            .:|.:.....|...      ||       .|:..|:|||::||..||:...|:...||:.|.|..
Human   341 QLFLVLQALGPAGS------WHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRVC 399

  Fly   382 FCRGASGRRKKR-GQHDTFCMHRD 404
            .|.....||.:| |..|....|.:
Human   400 PCAPRRPRRPRRPGPSDPAAPHAE 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tmA_Bombesin_R-like	82..377	CDD:320593	94/375 (25%)
		TM helix 1	83..109	CDD:320593	9/25 (36%)
		TM helix 2	116..142	CDD:320593	8/25 (32%)
		TM helix 3	154..184	CDD:320593	10/29 (34%)
		TM helix 4	201..221	CDD:320593	6/19 (32%)
		TM helix 5	252..277	CDD:320593	6/24 (25%)
		TM helix 6	300..330	CDD:320593	11/35 (31%)
		TM helix 7	345..370	CDD:320593	11/31 (35%)
KISS1R	XP_047295501.1	7tm_GPCRs	43..395	CDD:475119	94/375 (25%)
		TM helix 1	45..69	CDD:410628	9/23 (39%)
		TM helix 2	78..100	CDD:410628	8/21 (38%)
		TM helix 3	116..138	CDD:410628	6/21 (29%)
		TM helix 4	161..177	CDD:410628	4/15 (27%)
		TM helix 5	202..225	CDD:410628	5/22 (23%)
		TM helix 6	323..345	CDD:410628	7/21 (33%)
		TM helix 7	363..388	CDD:410628	10/24 (42%)