DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCHa1-R and TACR3

DIOPT Version :9

Sequence 1:	NP_611241.2	Gene:	CCHa1-R / 37004	FlyBaseID:	FBgn0050106	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001050.1	Gene:	TACR3 / 6870	HGNCID:	11528	Length:	465	Species:	Homo sapiens

Alignment Length:	472	Identity:	115/472 - (24%)
Similarity:	208/472 - (44%)	Gaps:	88/472 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 IANLVSMET--DLAMNIGLDTSGEAPTALPPMPNVTETLWDLAMVVSQSTQW-PLLDTGS--SEN 61
            :|.|.:.||  |....:|.|.           .|:|.:|...|...:..|.| .|||...  |.:
Human     1 MATLPAAETWIDGGGGVGADA-----------VNLTASLAAGAATGAVETGWLQLLDQAGNLSSS 54

  Fly    62 FSEL---VTTETPYVPYGRRPETYIVP--------ILFALIFVVGVLGNGTLIVVFLSVRQMRNV 115
            .|.|   |.:..|..|:......::.|        :.:.::..|.||||..:|.:.|:.::||.|
Human    55 PSALGLPVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTV 119

  Fly   116 PNTYILSLALADL-LVIITTVPLASTVYTV-EYWPYGSFLCSLSEFMKDVSIGVSVFTLTALSGD 178
            .|.::::||.:|. :....|  |.:.:|.: ..|.:|:..|....|....::..|::::||::.|
Human   120 TNYFLVNLAFSDASMAAFNT--LVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVD 182

  Fly   179 RYFAIVDPLRKFHAHGGGRRATRMTLATAVSIWLLAILCGLPALIGSNLKHLGINEKSIVICY-P 242
            ||.||:|||:.       |.:...|.....|||:||.|...|..:.|..|.:    ....:|: .
Human   183 RYMAIIDPLKP-------RLSATATKIVIGSIWILAFLLAFPQCLYSKTKVM----PGRTLCFVQ 236

  Fly   243 YPEEWGINYAKSMVLLHFLVYYAIPLVVIAVFYVLIALHLMYSASVPGEIQGAV-RQVRARRKVA 306
            :||....::...::::  ::.|..||:::.:.|.::.:.| :...:||:..... .|::|:|||.
Human   237 WPEGPKQHFTYHIIVI--ILVYCFPLLIMGITYTIVGITL-WGGEIPGDTCDKYHEQLKAKRKVV 298

  Fly   307 VTVLAFVVIFGICFLPYHVFFL----------WFYFWPTAQDDYNA-FWHVLRIVAYCMSFANSC 360
            ..::..|:.|.||:||||::|:          |.|.    |..|.| ||         ::.:::.
Human   299 KMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYI----QQVYLASFW---------LAMSSTM 350

  Fly   361 ANPVALYFVSGAFRKHFNR-YLFCRGASGRRKKRGQHDTFCMHRDTSLTSTASKRFQSRHSCYQS 424
            .||:....::..||..|.| :.:|...     |...:|      :..|.:|   ||.........
Human   351 YNPIIYCCLNKRFRAGFKRAFRWCPFI-----KVSSYD------ELELKTT---RFHPNRQSSMY 401

  Fly   425 TIRSCRLQETTITTLPN 441
            |:  .|::..|:...||
Human   402 TV--TRMESMTVVFDPN 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tm_4	88..>188	CDD:304433	31/101 (31%)
CCHa1-R	NP_611241.2	7tm_1	98..364	CDD:278431	72/280 (26%)
TACR3	NP_001050.1	7tmA_NKR_NK3R	86..367	CDD:320669	78/309 (25%)
		TM helix 1	87..113	CDD:320669	7/25 (28%)
		TM helix 2	120..146	CDD:320669	6/27 (22%)
		TM helix 3	158..188	CDD:320669	9/29 (31%)
		TM helix 4	199..220	CDD:320669	8/20 (40%)
		TM helix 5	244..273	CDD:320669	4/30 (13%)
		TM helix 6	292..322	CDD:320669	13/29 (45%)
		TM helix 7	335..360	CDD:320669	7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..465		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810