Protein Alignment CCHa1-R and TACR1

DIOPT Version :9

• Sequence 1: NP_611241.2
• Gene: CCHa1-R / 37004
• FlyBaseID: FBgn0050106
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_001049.1
• Gene: TACR1 / 6869
• HGNCID: 11526
• Length: 407
• Species: Homo sapiens
• Alignment Length: 469
• Identity: 113/469 - (24%)
• Similarity: 203/469 - (43%)
• Gaps: 106/469 - (22%)

  Fly     4 NLVSMETDLAMNIGLDTSGEAPTALPPMPN-VTETLWDLAMVVSQSTQWPLLDTGSSENFSELVT 67
            |::.:::||:.||..:||         .|| ..:..|.:.:       |
Human     3 NVLPVDSDLSPNISTNTS---------EPNQFVQPAWQIVL-------W---------------- 35

  Fly    68 TETPYVPYGRRPETYIVPILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVII 132
                             ...:.:|.|..|:||..::.:.|:.::||.|.|.::::||.|:
Human    36 -----------------AAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAE----- 78

  Fly   133 TTVPLASTVYTVEY-----WPYGSFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHA 192
            .::...:||....|     |.||.|.|....|....::..|::::||::.|||.||:.||:.
Human    79 ASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQP--- 140

  Fly   193 HGGGRRATRMTLATAVSIWLLAILCGLPALIGSNLKHLGINEKSIVIC-YPYPEEWGINYAKSMV 256
                |.:...|......||:||:|...|....|..:.:    .|.|:| ..:||.....|.|...
Human   141 ----RLSATATKVVICVIWVLALLLAFPQGYYSTTETM----PSRVVCMIEWPEHPNKIYEKVYH 197

  Fly   257 LLHFLVYYAIPLVVIAVFYVLIALHLMYSASVPGEIQGAV-RQVRARRKVAVTVLAFVVIFGICF 320
            :...::.|.:||:||...|.::.:.| :::.:||:..... .||.|:|||...::..|..|.||:
Human   198 ICVTVLIYFLPLLVIGYAYTVVGITL-WASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICW 261

  Fly   321 LPYHVFFLWFYFWPTAQDDY-NAFWHVLRIVAYCMSFANSCANPVALYFVSGAFRKHF-NRYLFC 383
            ||:|:|||..|..|   |.| ..|...:.:....::.:::..||:....::..||..| :.:..|
Human   262 LPFHIFFLLPYINP---DLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCC 323

  Fly   384 RGASGRRKKRGQHDTFCMHRDTSLTSTASKRFQSRHSCYQSTIRSCRLQETTITTL-------PN 441
            ...|.     |.::        .|...:::..|::.|.|:.:    || ||||:|:       |.
Human   324 PFISA-----GDYE--------GLEMKSTRYLQTQGSVYKVS----RL-ETTISTVVGAHEEEPE 370

  Fly   442 GGNQNGANISAVEL 455
            .|.:  |..|:::|
Human   371 DGPK--ATPSSLDL 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tm_4	88..>188	CDD:304433	31/104 (30%)
		7tm_1	98..364	CDD:278431	76/273 (28%)
TACR1	NP_001049.1	7tmA_NK1R	33..316	CDD:320668	83/342 (24%)
		TM helix 1	35..59	CDD:320668	6/56 (11%)
		TM helix 2	68..90	CDD:320668	6/26 (23%)
		TM helix 3	106..128	CDD:320668	4/21 (19%)
		TM helix 4	149..165	CDD:320668	5/15 (33%)
		TM helix 5	194..217	CDD:320668	6/22 (27%)
		TM helix 6	247..269	CDD:320668	8/21 (38%)
		TM helix 7	284..309	CDD:320668	2/24 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..407		5/21 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810