DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCHa1-R and BRS3

DIOPT Version :9

Sequence 1:	NP_611241.2	Gene:	CCHa1-R / 37004	FlyBaseID:	FBgn0050106	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001718.1	Gene:	BRS3 / 680	HGNCID:	1113	Length:	399	Species:	Homo sapiens

Alignment Length:	384	Identity:	135/384 - (35%)
Similarity:	205/384 - (53%)	Gaps:	54/384 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 ILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVIITTVPLASTVYTVEYWPYG 150
            |.:|:|..||:|||..||.||...:.|:.|||.:|.|||..|||:::|.||:.:|.|..|.|.:|
Human    52 ITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFG 116

  Fly   151 SFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRATRMTLATAVS---IWL 212
            ...|.:..|::..|:||||||||.||.|||.|:|.||.        |:.:...|.|.|.   :|:
Human   117 RIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLE--------RQPSNAILKTCVKAGCVWI 173

  Fly   213 LAILCGLPALIGSNLKHLGINEKSIVI--CYPYPEEWGINYAKSMV-----LLHFLVYYAIPLVV 270
            ::::..||..|.||:.......|::..  |..||      .:|.::     ||.|||:|.|||.:
Human   174 VSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYP------VSKKLLQEIHSLLCFLVFYIIPLSI 232

  Fly   271 IAVFYVLIALHLMYSA-SVPGEIQG-AVRQVRARRKVAVTVLAFVVIFGICFLPYHVFFLWFYFW 333
            |:|:|.|||..|..|. ::|.|.|. |.:|:.:|:::|.|||..|.:|.:|:||.|:.:|:..|.
Human   233 ISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFT 297

  Fly   334 PTAQDDYNAFWHVLRIVAYCMSFANSCANPVALYFVSGAFRKHFNRYLFCRGASGRRKKRGQHDT 398
            .....|.:|...:..|.:..::|:|||.||.|||::|.:|:|||...|||..|     :|.:...
Human   298 SQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKA-----ERPEPPV 357

  Fly   399 FCMHRDTSLTSTASKRFQSRHSCYQSTI---RSCRLQETTITTLPNGGNQNGANISAVE 454
                .|||||:.|          ...|:   .|.::.|.::|:.      .|.::...|
Human   358 ----ADTSLTTLA----------VMGTVPGTGSIQMSEISVTSF------TGCSVKQAE 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tm_4	88..>188	CDD:304433	49/99 (49%)
CCHa1-R	NP_611241.2	7tm_1	98..364	CDD:278431	103/277 (37%)
BRS3	NP_001718.1	7tmA_BRS-3	48..341	CDD:320251	116/302 (38%)
		TM helix 1	49..75	CDD:320251	12/22 (55%)
		TM helix 2	82..108	CDD:320251	13/25 (52%)
		TM helix 3	120..150	CDD:320251	17/29 (59%)
		TM helix 4	162..182	CDD:320251	5/19 (26%)
		TM helix 5	214..239	CDD:320251	12/24 (50%)
		TM helix 6	264..294	CDD:320251	12/29 (41%)
		TM helix 7	309..334	CDD:320251	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	177	1.000	Domainoid score	I3598
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3601
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153238at2759
OrthoFinder	1	1.000	-	-		FOG0001846
OrthoInspector	1	1.000	-	-		mtm8658
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45695
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4897
SonicParanoid	1	1.000	-	-		X1046
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	10.100