Protein Alignment CCHa1-R and NPY4R

DIOPT Version :10

• Sequence 1: NP_611241.2
• Gene: CCHa1-R / 37004
• FlyBaseID: FBgn0050106
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_005963.4
• Gene: NPY4R / 5540
• HGNCID: 9329
• Length: 375
• Species: Homo sapiens
• Alignment Length: 363
• Identity: 96/363 - (26%)
• Similarity: 170/363 - (46%)
• Gaps: 66/363 - (18%)

  Fly    41 LAMVVSQSTQW-----PLLDTGSSENFSELVTTETPYVPYGRRPETYIVPILFALIFVVGVLGNG 100
            ||:::.:|.|.     ||   |:..||||........:.:        :...:::..|||||||.
Human     7 LALLLPKSPQGENRSKPL---GTPYNFSEHCQDSVDVMVF--------IVTSYSIETVVGVLGNL 60

  Fly   101 TLIVVFLSVRQMRNVPNTYILSLALADLLVIITTVPLASTVYTV-EYWPYGSFLCSLSEFMKDVS 164
            .|:.|.:..::..||.|..|.:||.:|.|:.:...|| :.|||: :||.:|..||.:|.|::.:|
Human    61 CLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPL-TAVYTIMDYWIFGETLCKMSAFIQCMS 124

  Fly   165 IGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRATRMTLATAVSIWLLAILCGLPALIGS---N 226
            :.||:.:|..::.:|:..|::|.       |.:.:........|.||::|.:..||.|..|   |
Human   125 VTVSILSLVLVALERHQLIINPT-------GWKPSISQAYLGIVLIWVIACVLSLPFLANSILEN 182

  Fly   227 LKHLGINEKSI------VICYPYPEEWGINYAKSMVLLHFLVY-YAIPLVVIAVFYVLIALHLMY 284
            :.|.. :.|::      |:|   .|.|.:.:.:::.....|:: |.:||..|.|.|..|...|..
Human   183 VFHKN-HSKALEFLADKVVC---TESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRCLQR 243

  Fly   285 SASVPGEIQGAVRQVRA--RRKVAVTVLAFVVIFGICFLPYHVFFLWFYFWPTAQDDYNAFWH-- 345
            ...|   .......:||  .::|.|.::..||.|.:.:||.|||        .:.:|    ||
Human   244 QGRV---FHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVF--------NSLED----WHHE 293

  Fly   346 --------VLRIVAYCMSFANSCANPVALYFVSGAFRK 375
                    ::.:|.:.::.|::|.||....|::..|:|
Human   294 AIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKK 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tmA_Bombesin_R-like	82..377	CDD:320593	85/317 (27%)
		TM helix 1	83..109	CDD:320593	9/25 (36%)
		TM helix 2	116..142	CDD:320593	8/25 (32%)
		TM helix 3	154..184	CDD:320593	8/29 (28%)
		TM helix 4	201..221	CDD:320593	5/19 (26%)
		TM helix 5	252..277	CDD:320593	7/25 (28%)
		TM helix 6	300..330	CDD:320593	12/31 (39%)
		TM helix 7	345..370	CDD:320593	7/34 (21%)
NPY4R	NP_005963.4	7tmA_NPY4R	42..333	CDD:320519	85/325 (26%)
		TM helix 1	43..69	CDD:320519	9/33 (27%)
		TM helix 2	76..101	CDD:320519	8/25 (32%)
		TM helix 3	114..144	CDD:320519	8/29 (28%)
		TM helix 4	155..176	CDD:320519	6/20 (30%)
		TM helix 5	211..240	CDD:320519	8/28 (29%)
		TM helix 6	258..288	CDD:320519	10/37 (27%)
		TM helix 7	301..326	CDD:320519	6/24 (25%)