Protein Alignment CCHa1-R and OPRK1

DIOPT Version :10

• Sequence 1: NP_611241.2
• Gene: CCHa1-R / 37004
• FlyBaseID: FBgn0050106
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_001305426.1
• Gene: OPRK1 / 4986
• HGNCID: 8154
• Length: 409
• Species: Homo sapiens
• Alignment Length: 372
• Identity: 103/372 - (27%)
• Similarity: 174/372 - (46%)
• Gaps: 55/372 - (14%)

  Fly    24 APTA-LPPMPNVTETLWDLAMVVSQSTQWPLLDTGSSENFSELVTTE----TPYVPYGRRPETYI 83
            ||:| |||    ..:.|        ...|...|:..|.. ||....|    :|.:|       .|
Human    17 APSACLPP----NSSAW--------FPGWAEPDSNGSAG-SEDAQLEPAHISPAIP-------VI 61

  Fly    84 VPILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVIITTVPLASTVYTVEYWP 148
            :..:::::||||::||..::.|.:...:|:...|.||.:|||||.|| .||:|..||||.:..||
Human    62 ITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALV-TTTMPFQSTVYLMNSWP 125

  Fly   149 YGSFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRATRMTLATAVSIWLL 213
            :|..||.:...:...::..|:||||.:|.|||.|:..|::....     |.........:.||||
Human   126 FGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDF-----RTPLKAKIINICIWLL 185

  Fly   214 AILCGLPALI--GSNLKHLGINEKSIVIC-YPYPEE---WGINYAKSMVLLHFLVYYAIPLVVIA 272
            :...|:.|::  |:.::    .:..::.| ..:|::   |...:.|..|   |:..:.||:::|.
Human   186 SSSVGISAIVLGGTKVR----EDVDVIECSLQFPDDDYSWWDLFMKICV---FIFAFVIPVLIII 243

  Fly   273 VFYVLIALHLMYSASVPGEIQGAVRQVRARRKVAVTVLAFVVIFGICFLPYHVFFLWFYFWPTAQ 337
            |.|.|:.|.|. |..:   :.|:..:.|..|::...||..|.:|.:|:.|.|:|.|......|:.
Human   244 VCYTLMILRLK-SVRL---LSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSH 304

  Fly   338 DDYNAFWHVLRIVAYC--MSFANSCANPVALYFVSGAFRKHFNRYLF 382
            ..     ..|....:|  :.:.||..||:...|:...|::.|..:.|
Human   305 ST-----AALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCF 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tmA_Bombesin_R-like	82..377	CDD:320593	86/302 (28%)
		TM helix 1	83..109	CDD:320593	8/25 (32%)
		TM helix 2	116..142	CDD:320593	15/25 (60%)
		TM helix 3	154..184	CDD:320593	11/29 (38%)
		TM helix 4	201..221	CDD:320593	5/19 (26%)
		TM helix 5	252..277	CDD:320593	8/24 (33%)
		TM helix 6	300..330	CDD:320593	11/29 (38%)
		TM helix 7	345..370	CDD:320593	7/26 (27%)
OPRK1	NP_001305426.1	7tmA_Kappa_opioid_R	60..341	CDD:320219	86/302 (28%)
		TM helix 1	61..87	CDD:320219	8/25 (32%)
		TM helix 2	94..120	CDD:320219	16/26 (62%)
		TM helix 3	131..161	CDD:320219	11/29 (38%)
		TM helix 4	173..195	CDD:320219	6/21 (29%)
		TM helix 5	223..252	CDD:320219	9/31 (29%)
		TM helix 6	267..297	CDD:320219	11/29 (38%)
		TM helix 7	309..334	CDD:320219	7/24 (29%)