DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCHa1-R and PK1-R

DIOPT Version :9

Sequence 1:	NP_611241.2	Gene:	CCHa1-R / 37004	FlyBaseID:	FBgn0050106	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001014620.1	Gene:	PK1-R / 41713	FlyBaseID:	FBgn0038201	Length:	430	Species:	Drosophila melanogaster

Alignment Length:	459	Identity:	108/459 - (23%)
Similarity:	183/459 - (39%)	Gaps:	118/459 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 RRPETYIVP--ILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVIITTVPLAS 139
            |.|...::|  ::::|||:.||:||.:..:|....|.|....|.|:.|||::|.|::::.|| ..
  Fly    14 RDPLAIVIPVTVVYSLIFITGVVGNISTCIVIKKNRSMHTATNYYLFSLAISDFLLLLSGVP-QE 77

  Fly   140 TVYTVEYWPY--GSFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRATRM 202
            ..|....:||  |.::|.....:.:.|...:|.|:||.:.:||.||..|..       |:..:::
  Fly    78 VSYIWSKYPYVFGEYICIGRGLLAETSANATVLTITAFTVERYIAICHPFL-------GQAMSKL 135

  Fly   203 TLA--TAVSIWLLAILCGLPALIGSNLKHLGINEKSIVICYPYPEEWGI--NYAKSMVLLHFLVY 263
            :.|  ..|.:|::||:..:|......::|           |...|:.||  ...|....|...::
  Fly   136 SRAIRIIVLVWIMAIVTAIPQAAQFGIEH-----------YSGVEQCGIVRVIVKHSFQLSTFIF 189

  Fly   264 YAIPLVVIAVFYVLIALHLMYSASVPGEIQGAVRQ------------------------------ 298
            :..|:.:|.|.|:||.:||..|..|.|....|.||
  Fly   190 FLAPMSIILVLYLLIGVHLYRSTLVEGPASVARRQQLKSVPSDTILYRYGGSGTAMSFNGGGSGA 254

  Fly   299 ---------------VRAR------RKVAVTVLAFVVIFGICFLPYHVFFLWFYFWPT----AQD 338
                           ||.|      |:|...::|.||.|.:|:.|:|...|...:.|.    .:|
  Fly   255 GTAGLMGGSGAQLSSVRGRLNHYGTRRVLRMLVAVVVCFFLCWAPFHAQRLIAIYAPARGAKLRD 319

  Fly   339 DYNAFWHVLRIVAYCMSFANSCANPVALYFVSGAFRKHFNRYLFCRGASGRRKKRGQHDTFCMHR 403
            .:...:.|:..|:..:.:.::|.||:....:|..||:.|...||     |::..:|
  Fly   320 QHEFVYTVMTYVSGVLYYLSTCINPLLYNIMSHKFREAFKAVLF-----GKKVSKG--------- 370

  Fly   404 DTSLTSTASKRFQSRHSCYQSTIRSCRLQETTITTLPNGGNQNGANISAVELALPVLQAPGHNEA 468
              ||.|             ::.|.|.||:.    .|.|.......:|.:.|...|.:.   .|..
  Fly   371 --SLNS-------------RNNIESRRLRR----ALTNSSQTQRFSIESAEQPKPSIM---QNPT 413

  Fly   469 HAPP 472
            :.||
  Fly   414 NKPP 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tm_4	88..>188	CDD:304433	34/101 (34%)
CCHa1-R	NP_611241.2	7tm_1	98..364	CDD:278431	76/326 (23%)
PK1-R	NP_001014620.1	7tmA_capaR	21..358	CDD:320262	86/355 (24%)
		TM helix 1	21..48	CDD:320262	9/26 (35%)
		TM helix 2	55..81	CDD:320262	9/26 (35%)
		TM helix 3	94..124	CDD:320262	9/29 (31%)
		TM helix 4	136..158	CDD:320262	6/21 (29%)
		TM helix 5	178..207	CDD:320262	8/28 (29%)
		TM helix 6	277..307	CDD:320262	10/29 (34%)
		TM helix 7	326..351	CDD:320262	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438997
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840