Protein Alignment CCHa1-R and oprk1

DIOPT Version :10

• Sequence 1: NP_611241.2
• Gene: CCHa1-R / 37004
• FlyBaseID: FBgn0050106
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_001305709.1
• Gene: oprk1 / 360139
• ZFINID: ZDB-GENE-030729-1
• Length: 404
• Species: Danio rerio
• Alignment Length: 446
• Identity: 113/446 - (25%)
• Similarity: 193/446 - (43%)
• Gaps: 86/446 - (19%)

  Fly    23 EAPTALPP--MPNVTETLWDLAMVVSQSTQWPLLDTGSSENFSELVTTETPYVPYGRRPETYIVP 85
            :.|::.|.  :||.|   |       ||....:.::..:|:::......:|.:|        |:.
Zfish    13 KCPSSHPEKCLPNFT---W-------QSAVSDIYNSSLNESWTTEQEAMSPLIP--------IIT 59

  Fly    86 ILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVIITTVPLASTVYTVEYWPYG 150
            .:::::||||::||..::.|.:...:|:...|.||.:||:||.|| .||:|..||.|.:..||:|
Zfish    60 AVYSVVFVVGLVGNCLVMYVIIRYTKMKTATNIYIFNLAVADALV-TTTMPFQSTDYLLNSWPFG 123

  Fly   151 SFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRATRMTLATAVSIWLLAI 215
            ..:|.:...:...::..|:||||.:|.|||.|:..|::....     |.........:.||:|:.
Zfish   124 EVVCKVFISIDYYNMFTSIFTLTMMSVDRYVAVCHPVKALDF-----RTPMKAKIINILIWVLSS 183

  Fly   216 LCGLPALI-GSNLKHLGINEKSIVICYPYPEEWGINYAKSMVLLHFLVYYAIPLVVIAVFYVLIA 279
            ..|:||:: ||...:.|..|.::....||     :.:...|.:..|:..:..||::|.|.|.|:.
Zfish   184 AAGIPAMVLGSTQTNNGTTECALQFPDPY-----VYWDTLMKICVFIFGFVAPLLIITVCYTLMV 243

  Fly   280 LHLMYSASVPGEIQGAVRQVRARRKVAVTVLAFVVIFGICFLPYHVFFLWFYFWPTAQDDYNAFW 344
            |.|. |..:   :.|:..:.|..|::...||..|.:|.:|:.|.|:|.|           ..|..
Zfish   244 LRLK-SVRL---LSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFIL-----------VKALS 293

  Fly   345 H-------VLRIVAYC--MSFANSCANPVALYFVSGAFRKHFNRYLFCRGASGRRKKRGQHDTFC 400
            |       |:....:|  :.:.||..||:...|:...|::.|..  ||  ..||....|:.
Zfish   294 HGVPETTSVMAAYFFCVALGYTNSSLNPILYAFLDENFKRCFRD--FC--CPGRTAGDGRG---- 350

  Fly   401 MHRDTSLTSTASKRFQSRHSCYQSTIRSCRLQETTITTLPNGGNQNGANISAVELA 456
                                  .|.:||...:.|......|.|.|......||||:
Zfish   351 ----------------------VSRVRSTLREHTCPAEAKNDGGQGRPVXLAVELS 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tmA_Bombesin_R-like	82..377	CDD:320593	85/304 (28%)
		TM helix 1	83..109	CDD:320593	8/25 (32%)
		TM helix 2	116..142	CDD:320593	14/25 (56%)
		TM helix 3	154..184	CDD:320593	11/29 (38%)
		TM helix 4	201..221	CDD:320593	4/19 (21%)
		TM helix 5	252..277	CDD:320593	7/24 (29%)
		TM helix 6	300..330	CDD:320593	11/29 (38%)
		TM helix 7	345..370	CDD:320593	8/33 (24%)
oprk1	NP_001305709.1	7tmA_Kappa_opioid_R	56..335	CDD:320219	86/312 (28%)
		TM helix 1	57..83	CDD:320219	8/25 (32%)
		TM helix 2	90..116	CDD:320219	14/26 (54%)
		TM helix 3	127..157	CDD:320219	11/29 (38%)
		TM helix 4	169..191	CDD:320219	6/21 (29%)
		TM helix 5	216..245	CDD:320219	8/28 (29%)
		TM helix 6	260..290	CDD:320219	11/40 (28%)
		TM helix 7	303..328	CDD:320219	6/24 (25%)