DRSC/TRiP Functional Genomics Resources

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Protein Alignment CCHa1-R and HCRTR1

DIOPT Version :10

Sequence 1:NP_611241.2 Gene:CCHa1-R / 37004 FlyBaseID:FBgn0050106 Length:499 Species:Drosophila melanogaster
Sequence 2:NP_001516.2 Gene:HCRTR1 / 3061 HGNCID:4848 Length:425 Species:Homo sapiens


Alignment Length:414 Identity:109/414 - (26%)
Similarity:173/414 - (41%) Gaps:85/414 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 PETY--IVPILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVIITTVPLASTV 141
            |:.|  ::...:..:|||.::||..:.:.......||.|.|.:|::|:|||:||....:|.:..|
Human    42 PKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLV 106

  Fly   142 YTVEYWPYGSFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRATRMTLAT 206
            ...|.|.:|..||.:..:::.||:.|:|.||:.::.||::||..||.       .:...|....:
Human   107 DITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLL-------FKSTARRARGS 164

  Fly   207 AVSIWL--LAILCGLPALI--GSNLKHLGINEKSIVICYPYPEEWGIN-YAKSMVLLHFLVYYAI 266
            .:.||.  |||:....|::  .|.|..|....:...:|   .|.|..: |.|......|:|.|..
Human   165 ILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVC---DERWADDLYPKIYHSCFFIVTYLA 226

  Fly   267 PLVVIAVFYVLIALHLMYSASVPGEIQGAVR--------------------------------QV 299
            ||.::|:.|..| ...::...:||.....||                                |:
Human   227 PLGLMAMAYFQI-FRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQM 290

  Fly   300 RARRKVAVTVLAFVVIFGICFLPYHVFFLW---FYFWPTAQDDYNAFWHVLRIVAY-CMSF---- 356
            |||||.|..::..:::|.:|:||..|..:.   |..:..|.|         |...| |.:|    
Human   291 RARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASD---------REAVYACFTFSHWL 346

  Fly   357 --ANSCANPVALYFVSGAFRKHFNRYLFC----RGASGRRKKRGQHDTFCMHRDTSLTSTASKRF 415
              |||.|||:...|:||.||:.|.....|    .|..|..|......: ..|:..||.|..|...
Human   347 VYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSS-ASHKSLSLQSRCSISK 410

  Fly   416 QSRHSCYQSTIRSCRLQETTITTL 439
            .|.|           :..|::||:
Human   411 ISEH-----------VVLTSVTTV 423

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CCHa1-RNP_611241.2 7tmA_Bombesin_R-like 82..377 CDD:320593 93/343 (27%)
TM helix 1 83..109 CDD:320593 5/25 (20%)
TM helix 2 116..142 CDD:320593 9/25 (36%)
TM helix 3 154..184 CDD:320593 10/29 (34%)
TM helix 4 201..221 CDD:320593 6/21 (29%)
TM helix 5 252..277 CDD:320593 8/24 (33%)
TM helix 6 300..330 CDD:320593 11/32 (34%)
TM helix 7 345..370 CDD:320593 11/31 (35%)
HCRTR1NP_001516.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
Required for response to orexin-A. /evidence=ECO:0000269|PubMed:26950369 26..41
7tmA_OXR 47..369 CDD:320336 92/341 (27%)
TM helix 1 48..74 CDD:320336 5/25 (20%)
TM helix 2 81..107 CDD:320336 9/25 (36%)
TM helix 3 119..149 CDD:320336 10/29 (34%)
TM helix 4 160..181 CDD:320336 5/20 (25%)
TM helix 5 212..241 CDD:320336 9/29 (31%)
TM helix 6 291..321 CDD:320336 11/29 (38%)
TM helix 7 337..362 CDD:320336 10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

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