DRSC/TRiP Functional Genomics Resources

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Protein Alignment CCHa1-R and GRPR

DIOPT Version :9

Sequence 1:NP_611241.2 Gene:CCHa1-R / 37004 FlyBaseID:FBgn0050106 Length:499 Species:Drosophila melanogaster
Sequence 2:NP_005305.1 Gene:GRPR / 2925 HGNCID:4609 Length:384 Species:Homo sapiens


Alignment Length:339 Identity:132/339 - (38%)
Similarity:202/339 - (59%) Gaps:25/339 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 YIVPILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVIITTVPLASTVYTVEY 146
            |::|.::.:|.::|::||.|||.:|.:|:.||||||.:|.||||.|||::||..|:.::.|..:.
Human    41 YVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADR 105

  Fly   147 WPYGSFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRATRMTLATAVSIW 211
            |.:|...|.|..|::..|:|||||||||||.|||.|||.|:....:|     |.......|..||
Human   106 WLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASH-----ALMKICLKAAFIW 165

  Fly   212 LLAILCGLPALIGSNLK--HLGINEKSIVICYPYPEEWGINYAKSMVLLHFLVYYAIPLVVIAVF 274
            ::::|..:|..:.|:|.  |.....::.:.|.|||....: :.|...:..|||:|.|||.:|:|:
Human   166 IISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNEL-HPKIHSMASFLVFYVIPLSIISVY 229

  Fly   275 YVLIALHLMYSA-SVPGEIQGAV---RQVRARRKVAVTVLAFVVIFGICFLPYHVFFLW--FYFW 333
            |..||.:|:.|| ::|  ::|.:   :|:.:|:::|.|||.||.:|..|:||.||.:|:  ::: 
Human   230 YYFIAKNLIQSAYNLP--VEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHY- 291

  Fly   334 PTAQDDYNAFWHVLRIVAYCMSFANSCANPVALYFVSGAFRKHFNRYLFC--RGASGRRKKRGQH 396
              ::.|.:....|..|.|..::|.|||.||.|||.:|.:|||.||..|.|  .|...|....|: 
Human   292 --SEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGR- 353

  Fly   397 DTFCMHRDTSLTST 410
            .|.||   |||.||
Human   354 STTCM---TSLKST 364

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CCHa1-RNP_611241.2 7tm_4 88..>188 CDD:304433 51/99 (52%)
7tm_1 98..364 CDD:278431 105/273 (38%)
GRPRNP_005305.1 7tmA_GRPR 41..333 CDD:320252 117/302 (39%)
TM helix 1 42..68 CDD:320252 9/25 (36%)
TM helix 2 75..101 CDD:320252 13/25 (52%)
TM helix 3 113..143 CDD:320252 19/29 (66%)
TM helix 4 155..175 CDD:320252 4/19 (21%)
TM helix 5 207..232 CDD:320252 11/24 (46%)
TM helix 6 257..287 CDD:320252 14/29 (48%)
TM helix 7 301..326 CDD:320252 12/24 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 177 1.000 Domainoid score I3598
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 217 1.000 Inparanoid score I3601
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1153238at2759
OrthoFinder 1 1.000 - - FOG0001846
OrthoInspector 1 1.000 - - mtm8658
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45695
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4897
SonicParanoid 1 1.000 - - X1046
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1010.100

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