DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCHa1-R and GPR39

DIOPT Version :9

Sequence 1:	NP_611241.2	Gene:	CCHa1-R / 37004	FlyBaseID:	FBgn0050106	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001499.1	Gene:	GPR39 / 2863	HGNCID:	4496	Length:	453	Species:	Homo sapiens

Alignment Length:	466	Identity:	102/466 - (21%)
Similarity:	188/466 - (40%)	Gaps:	106/466 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 ILFALIFVVGVLGNGTLIVVFLSVRQ---MRNVPNTYILSLALADLLVIITTV----------PL 137
            :::.:|||:|:|||...|.|...:::   ::.....:::|||.:|:||.:..:          ||
Human    35 LVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPL 99

  Fly   138 ASTVYTVEYWPYGSFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRATRM 202
            .::.||:.        |.|..|:.:.....::..:..||.:||.||..|.| :.|..|   ..::
Human   100 TTSSYTLS--------CKLHTFLFEACSYATLLHVLTLSFERYIAICHPFR-YKAVSG---PCQV 152

  Fly   203 TLATAVSIWLLAILCGLPALIGSNLK--------HLGI--NEKS-----------IVICYPYPEE 246
            .|.... :|:.:.|..||.|.....:        |.|:  |..|           :.||......
Human   153 KLLIGF-VWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSR 216

  Fly   247 WGINYAKSMVLLHFLVYYAIPLVVIAVFYVLIALHLMYSASVPGEIQGAVR--QVR--------- 300
            |.:  .:|.:...|:||.   :|:::|.::...:..:...|..|.:.|..|  |:|
Human   217 WTV--FQSSIFGAFVVYL---VVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRT 276

  Fly   301 ARRKVAVTVLAFVVIFGICFLPYHVFFLWF-----YFWPTAQDDYNAFWHVLRIVAYCMSFANSC 360
            |||:..:.:...||...:|::|..:..:..     :.|..:   |...:.:|...:....:.:|.
Human   277 ARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRS---YFRAYMILLPFSETFFYLSSV 338

  Fly   361 ANPVALYFVSG-AFRKHFNRYLFCRGA---SGRRKKRGQHDTFCMHRDTSLTSTASKRFQSRHSC 421
            .||: ||.||. .||:.|.:.|.||.:   :...|:...|         :.::|.|.||..|...
Human   339 INPL-LYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVH---------AHSTTDSARFVQRPLL 393

  Fly   422 YQSTIRSC--RLQETTITTLPNGGNQNGANISAVELALPVLQAPGHNEAHAPPSYGFLPLNEIVQ 484
            :.|..:|.  |.::..::|..:.......:.|   |:|..|:          |:.|..|.|...:
Human   394 FASRRQSSARRTEKIFLSTFQSEAEPQSKSQS---LSLESLE----------PNSGAKPANSAAE 445

  Fly   485 QTRSSPAKFQE 495
            .      .|||
Human   446 N------GFQE 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tm_4	88..>188	CDD:304433	29/112 (26%)
CCHa1-R	NP_611241.2	7tm_1	98..364	CDD:278431	64/315 (20%)
GPR39	NP_001499.1	7tmA_GPR39	31..355	CDD:320263	76/341 (22%)
		TM helix 1	31..58	CDD:320263	9/22 (41%)
		TM helix 2	68..94	CDD:320263	6/25 (24%)
		TM helix 3	108..138	CDD:320263	8/29 (28%)
		TM helix 4	150..172	CDD:320263	5/22 (23%)
		TM helix 5	217..246	CDD:320263	7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..274		5/18 (28%)
		TM helix 6	276..306	CDD:320263	7/29 (24%)
		TM helix 7	323..348	CDD:320263	7/25 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..453		11/55 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910