DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCHa1-R and GPR37

DIOPT Version :9

Sequence 1:	NP_611241.2	Gene:	CCHa1-R / 37004	FlyBaseID:	FBgn0050106	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_005293.1	Gene:	GPR37 / 2861	HGNCID:	4494	Length:	613	Species:	Homo sapiens

Alignment Length:	381	Identity:	86/381 - (22%)
Similarity:	157/381 - (41%)	Gaps:	66/381 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 GSSENFSELVTTETPYVP-----YGRRPETYIVPILFALIFVVGVLGNGTLIVVFLSVRQMRNVP 116
            |:|.|  ..|..:.|:.|     ||    .|.|..|..:||..|::||..::.:......||::.
Human   238 GNSTN--RRVRLKNPFYPLTQESYG----AYAVMCLSVVIFGTGIIGNLAVMCIVCHNYYMRSIS 296

  Fly   117 NTYILSLALADLLVIITTVPLASTVYTVEYWPYGSFLCSLSEFMKDVSIGVSVFTLTALSGDRYF 181
            |:.:.:||..|.|:|...:||.......:.|....|.|.:..:::..|:||:.|||.||..||:
Human   297 NSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPYIEVASLGVTTFTLCALCIDRF- 360

  Fly   182 AIVDPLRKFHAHGGGRRATRM------------TLATAVSIWLLAILCGLPALIGSNL--KHLGI 232
                           |.||.:            |.|....||:.|:|..||.::...|  :.||.
Human   361 ---------------RAATNVQMYYEMIENCSSTTAKLAVIWVGALLLALPEVVLRQLSKEDLGF 410

  Fly   233 N-----EKSIVICYP-YPEE---WGINYAKSMVLLHFLVYYAIPLVVIAVFYVLIALHLMYSASV 288
            :     |:.|:...| .|:.   ..:.|..:.:..:|..|:.:|.:......::.|..:..:...
Human   411 SGRAPAERCIIKISPDLPDTIYVLALTYDSARLWWYFGCYFCLPTLFTITCSLVTARKIRKAEKA 475

  Fly   289 PGEIQGAVRQVRARRKVAVTVLAFVVIFGICFLPYHVFFLWFYFWPTAQDDYNAFWHVLRIVAYC 353
            .  .:|..||::...::..||:|..:::|.|.:|.::..:...:..|......  ..:|.|::..
Human   476 C--TRGNKRQIQLESQMNCTVVALTILYGFCIIPENICNIVTAYMATGVSQQT--MDLLNIISQF 536

  Fly   354 MSFANSCANPVALYFVSGAFRKHFNRYLFCRGASGRRKKRGQHDTFCMHRDTSLTS 409
            :.|..||..||.|:.:...|.:.|.....|....            |:.:.:::||
Human   537 LLFFKSCVTPVLLFCLCKPFSRAFMECCCCCCEE------------CIQKSSTVTS 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tm_4	88..>188	CDD:304433	28/99 (28%)
CCHa1-R	NP_611241.2	7tm_1	98..364	CDD:278431	63/288 (22%)
GPR37	NP_005293.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..138
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..172
		7tmA_GPR37	262..560	CDD:320255	73/317 (23%)
		TM helix 1	263..289	CDD:320255	7/25 (28%)
		TM helix 2	296..322	CDD:320255	8/25 (32%)
		TM helix 3	334..364	CDD:320255	12/45 (27%)
		TM helix 4	377..397	CDD:320255	7/19 (37%)
		TM helix 5	439..464	CDD:320255	3/24 (13%)
		TM helix 6	485..515	CDD:320255	6/29 (21%)
		TM helix 7	528..553	CDD:320255	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910