DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCHa1-R and MRGPRX1

DIOPT Version :9

Sequence 1:	NP_611241.2	Gene:	CCHa1-R / 37004	FlyBaseID:	FBgn0050106	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001380507.1	Gene:	MRGPRX1 / 259249	HGNCID:	17962	Length:	322	Species:	Homo sapiens

Alignment Length:	343	Identity:	83/343 - (24%)
Similarity:	142/343 - (41%)	Gaps:	95/343 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 TTETPYVPYGRRPETYI------VPILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLAL 125
            |.:|...|.....||..      :.:|..::.:||:.|| .:::..|..|..||..:.|||:||.
Human     7 TLDTELTPINGTEETLCYKQTLSLTVLTCIVSLVGLTGN-AVVLWLLGCRMRRNAFSIYILNLAA 70

  Fly   126 ADLL-----VIITTVPLASTVYTVEYWPYG----SFLCSLSEFMKDVSIGVSVFTLTALSGDRYF 181
            ||.|     :|.:.:...|..:|:....|.    |:...||             .|:|:|.:|..
Human    71 ADFLFLSGRLIYSLLSFISIPHTISKILYPVMMFSYFAGLS-------------FLSAVSTERCL 122

  Fly   182 AIVDPLRKFHAHGGGRRATRMTLATAVSIWLLAILCGLPALIGSNLKHLGINEKSIVICYPYPEE 246
            :::.|: .:..|    |.|.::....|.:|.|::|                  :||:       |
Human   123 SVLWPI-WYRCH----RPTHLSAVVCVLLWALSLL------------------RSIL-------E 157

  Fly   247 W--------GINYA----KSMVLLHFLVYYAIPLVVIAVFYVLIALHLMYSASVPGEIQGAVRQV 299
            |        |.:.|    ...:.:.:|::..:  |:.....||:...|..|..:|
Human   158 WMLCGFLFSGADSAWCQTSDFITVAWLIFLCV--VLCGSSLVLLIRILCGSRKIP---------- 210

  Fly   300 RARRKVAVTVLAFVVIFGICFLPYHV---FFLWFYFWPTAQDDYNAFWHVLRIVAYCMSFANSCA 361
              ..::.||:|..|::|.:|.||:.:   .|||.:.     |....|.|| .:|:..:|..||.|
Human   211 --LTRLYVTILLTVLVFLLCGLPFGIQFFLFLWIHV-----DREVLFCHV-HLVSIFLSALNSSA 267

  Fly   362 NPVALYFVSGAFRKHFNR 379
            ||: :||..|:||:..||
Human   268 NPI-IYFFVGSFRQRQNR 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tm_4	88..>188	CDD:304433	28/108 (26%)
CCHa1-R	NP_611241.2	7tm_1	98..364	CDD:278431	67/289 (23%)
MRGPRX1	NP_001380507.1	7tmA_MrgprX-like	28..299	CDD:320234	78/322 (24%)
		TM helix 1	30..54	CDD:320234	6/24 (25%)
		TM helix 2	62..84	CDD:320234	9/21 (43%)
		TM helix 3	98..118	CDD:320234	6/32 (19%)
		TM helix 4	141..157	CDD:320234	6/40 (15%)
		TM helix 5	178..201	CDD:320234	4/24 (17%)
		TM helix 6	215..237	CDD:320234	8/21 (38%)
		TM helix 7	251..276	CDD:320234	11/26 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910