Protein Alignment CCHa1-R and Hcrtr1

DIOPT Version :10

• Sequence 1: NP_611241.2
• Gene: CCHa1-R / 37004
• FlyBaseID: FBgn0050106
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_037196.1
• Gene: Hcrtr1 / 25593
• RGDID: 2787
• Length: 416
• Species: Rattus norvegicus
• Alignment Length: 445
• Identity: 111/445 - (24%)
• Similarity: 178/445 - (40%)
• Gaps: 98/445 - (22%)

  Fly    52 PLLDTGSSENFSELVTTETPYVPYGRR----PETY--IVPILFALIFVVGVLGNGTLIVVFLSVR 110
            |.:.|.|.|.|......|..::.|..|    |:.|  ::...:..:|::.::||..:.:......
  Rat    11 PGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNH 75

  Fly   111 QMRNVPNTYILSLALADLLVIITTVPLASTVYTVEYWPYGSFLCSLSEFMKDVSIGVSVFTLTAL 175
            .||.|.|.:|::|:|||:||....:|.:..|...|.|.:|..||.:..:::.||:.|:|.||:.:
  Rat    76 HMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 140

  Fly   176 SGDRYFAIVDPLRKFHAHGGGRRATRMTLATAVSIWLLAILCGLPAL----IGSNLKHLGINEKS 236
            :.||::||..||.       .:...|....:.:.||.:::...:|..    ..|.|..|....:.
  Rat   141 ALDRWYAICHPLL-------FKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRL 198

  Fly   237 IVICYPYPEEWGIN-YAKSMVLLHFLVYYAIPLVVIAVFYVLIALHLMYSASVPGEIQGAVR--- 297
            ..:|   .|.|... |.|......|.|.|..||.::.:.|..| ...::...:||.....||
  Rat   199 FSVC---DERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQI-FRKLWGPQIPGTTSALVRNWK 259

  Fly   298 -----------------------------QVRARRKVAVTVLAFVVIFGICFLPYHVFFLW---F 330
                                         |:|||||.|..::..:::|.:|:||..|..:.   |
  Rat   260 RPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVF 324

  Fly   331 YFWPTAQDDYNAFWHVLRIVAY-CMSF------ANSCANPVALYFVSGAFRKHFNRYLFC----R 384
            ..:..|.|         |...| |.:|      |||.|||:...|:||.||:.|.....|    .
  Rat   325 GMFRQASD---------REAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGL 380

  Fly   385 GASGRRKKRGQHDTFCMHRDTSLTSTASKRFQSRHSCYQSTIRSCRLQETTITTL 439
            |.|...:          |:..||.|..|....|.|           :..||:||:
  Rat   381 GPSSSAR----------HKSLSLQSRCSVSKVSEH-----------VVLTTVTTV 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tmA_Bombesin_R-like	82..377	CDD:320593	87/343 (25%)
		TM helix 1	83..109	CDD:320593	3/25 (12%)
		TM helix 2	116..142	CDD:320593	9/25 (36%)
		TM helix 3	154..184	CDD:320593	10/29 (34%)
		TM helix 4	201..221	CDD:320593	3/19 (16%)
		TM helix 5	252..277	CDD:320593	7/24 (29%)
		TM helix 6	300..330	CDD:320593	11/32 (34%)
		TM helix 7	345..370	CDD:320593	11/31 (35%)
Hcrtr1	NP_037196.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		4/10 (40%)
		Required for response to orexin-A. /evidence=ECO:0000250|UniProtKB:O43613	26..41		3/14 (21%)
		7tmA_OXR	47..369	CDD:320336	86/341 (25%)
		TM helix 1	48..74	CDD:320336	3/25 (12%)
		TM helix 2	81..107	CDD:320336	9/25 (36%)
		TM helix 3	119..149	CDD:320336	10/29 (34%)
		TM helix 4	160..181	CDD:320336	3/20 (15%)
		TM helix 5	212..241	CDD:320336	8/29 (28%)
		TM helix 6	291..321	CDD:320336	11/29 (38%)
		TM helix 7	337..362	CDD:320336	10/24 (42%)