DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa1-R and Tacr1

DIOPT Version :9

Sequence 1:	NP_611241.2	Gene:	CCHa1-R / 37004	FlyBaseID:	FBgn0050106	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_033339.2	Gene:	Tacr1 / 21336	MGIID:	98475	Length:	407	Species:	Mus musculus

Alignment Length:	400	Identity:	108/400 - (27%)
Similarity:	190/400 - (47%)	Gaps:	55/400 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 STQWPLLDTGSSENFSELVTTETPYVPYGRRPETYIV--PILFALIFVVGVLGNGTLIVVFLSVR 110
            |..:|...|.:||: ::.|           :|...||  ...:.:|.|..|:||..:|.:.|:.:
Mouse     9 SDLFPNTSTNTSES-NQFV-----------QPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHK 61

  Fly   111 QMRNVPNTYILSLALAD--LLVIITTVPLASTVYTVEYWPYGSFLCSLSEFMKDVSIGVSVFTLT 173
            :||.|.|.::::||.|:  :....|.|.....|:.|  |.||.|.|....|....::..|::::|
Mouse    62 RMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNV--WYYGLFYCKFHNFFPIAALFASIYSMT 124

  Fly   174 ALSGDRYFAIVDPLRKFHAHGGGRRATRMTLATAVSIWLLAILCGLPALIGSNLKHLGINEKSIV 238
            |::.|||.||:.||:.       |.:...|......||:||:|...|....|..:.:    .|.|
Mouse   125 AVAFDRYMAIIHPLQP-------RLSATATKVVIFVIWVLALLLAFPQGYYSTTETM----PSRV 178

  Fly   239 IC-YPYPEEWGINYAKSMVLLHFLVYYAIPLVVIAVFYVLIALHLMYSASVPGEIQGAV-RQVRA 301
            :| ..:||.....|.|:..:...::.|.:||:||...|.::.:.| :::.:||:..... .||.|
Mouse   179 VCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITL-WASEIPGDSSDRYHEQVSA 242

  Fly   302 RRKVAVTVLAFVVIFGICFLPYHVFFLWFYFWPTAQDDY-NAFWHVLRIVAYCMSFANSCANPVA 365
            :|||...::..|..|.||:||:|:|||..|..|   |.| ..|...:.:.:..::.:::..||:.
Mouse   243 KRKVVKMMIVVVCTFAICWLPFHIFFLLPYINP---DLYLKKFIQQVYLASMWLAMSSTMYNPII 304

  Fly   366 LYFVSGAFRKHF-NRYLFCRGASGRRKKRGQHDTFCMHRDTSLTSTASKRFQSRHSCYQSTIRSC 429
            ...::..||..| :.:..|...|.     |.::        .|...:::..|::.|.|:.:
Mouse   305 YCCLNDRFRLGFKHAFRCCPFISA-----GDYE--------GLEMKSTRYLQTQSSVYKVS---- 352

  Fly   430 RLQETTITTL 439
            || ||||:|:
Mouse   353 RL-ETTISTV 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tm_4	88..>188	CDD:304433	33/101 (33%)
CCHa1-R	NP_611241.2	7tm_1	98..364	CDD:278431	78/270 (29%)
Tacr1	NP_033339.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		3/10 (30%)
		7tm_GPCRs	33..316	CDD:391938	85/299 (28%)
		TM helix 1	35..59	CDD:341315	6/23 (26%)
		TM helix 2	68..90	CDD:341315	6/21 (29%)
		TM helix 3	106..128	CDD:341315	4/21 (19%)
		TM helix 4	149..165	CDD:341315	5/15 (33%)
		TM helix 5	194..217	CDD:341315	6/22 (27%)
		TM helix 6	244..269	CDD:341315	11/24 (46%)
		TM helix 7	284..309	CDD:341315	2/24 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..407		108/399 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810