DRSC/TRiP Functional Genomics Resources

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Protein Alignment CCHa1-R and Oprm1

DIOPT Version :10

Sequence 1:NP_611241.2 Gene:CCHa1-R / 37004 FlyBaseID:FBgn0050106 Length:499 Species:Drosophila melanogaster
Sequence 2:NP_001291884.1 Gene:Oprm1 / 18390 MGIID:97441 Length:474 Species:Mus musculus


Alignment Length:388 Identity:98/388 - (25%)
Similarity:172/388 - (44%) Gaps:61/388 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 LFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVIITTVPLASTVYTVEYWPYGS 151
            |::::.|||:.||..::.|.:...:|:...|.||.:|||||.|. .:|:|..|..|.:..||:|:
Mouse    74 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSVNYLMGTWPFGN 137

  Fly   152 FLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRATRMTLATAVSIWLLAIL 216
            .||.:...:...::..|:|||..:|.|||.|:..|::....     |..|......|..|:|:..
Mouse   138 ILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF-----RTPRNAKIVNVCNWILSSA 197

  Fly   217 CGLPALIGSNLKHLGINEKSI--VICYPYPEEWGINYAKSMVLLHFLVYYAIPLVVIAVFYVLIA 279
            .|||.:..:..|:   .:.||  .:.:.:|..:..|..|..|   |:..:.:|:::|.|.|.|:.
Mouse   198 IGLPVMFMATTKY---RQGSIDCTLTFSHPTWYWENLLKICV---FIFAFIMPVLIITVCYGLMI 256

  Fly   280 LHLMYSASVPGEIQGAVRQVRARRKVAVTVLAFVVIFGICFLPYHVFFLWFYFWPTAQDDYNAF- 343
            |.|   .|| ..:.|:..:.|..|::...||..|.:|.:|:.|.|::.:........:..:... 
Mouse   257 LRL---KSV-RMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVS 317

  Fly   344 WHVLRIVAYC--MSFANSCANPVALYFVSGAFRKHFNRYLFCRGASGRRKKRGQHDTFCMHRDTS 406
            ||      :|  :.:.|||.|||...|:...|::.|..                   ||:...::
Mouse   318 WH------FCIALGYTNSCLNPVLYAFLDENFKRCFRE-------------------FCIPTSST 357

  Fly   407 LTSTASKRFQSRHSCYQSTIRSCRLQETTITTLPNGGNQNGANISAVEL--ALPVLQAPGHNE 467
            :....|.|.:      |:|    |...:|..|:....:|....:|..::  ..|   :|.|.|
Mouse   358 IEQQNSARIR------QNT----REHPSTANTVDRTNHQPTLAVSVAQIFTGYP---SPTHVE 407

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CCHa1-RNP_611241.2 7tmA_Bombesin_R-like 82..377 CDD:320593 82/294 (28%)
TM helix 1 83..109 CDD:320593 7/21 (33%)
TM helix 2 116..142 CDD:320593 12/25 (48%)
TM helix 3 154..184 CDD:320593 10/29 (34%)
TM helix 4 201..221 CDD:320593 6/19 (32%)
TM helix 5 252..277 CDD:320593 7/24 (29%)
TM helix 6 300..330 CDD:320593 9/29 (31%)
TM helix 7 345..370 CDD:320593 9/26 (35%)
Oprm1NP_001291884.1 7tmA_Mu_opioid_R 69..347 CDD:320218 82/294 (28%)
TM helix 1 70..96 CDD:320218 7/21 (33%)
TM helix 2 103..129 CDD:320218 12/26 (46%)
TM helix 3 140..170 CDD:320218 10/29 (34%)
TM helix 4 182..204 CDD:320218 7/21 (33%)
TM helix 5 229..258 CDD:320218 9/31 (29%)
TM helix 6 273..303 CDD:320218 9/29 (31%)
TM helix 7 315..340 CDD:320218 10/30 (33%)
NPxxY, plays a role in stabilizing the activated conformation of the receptor. /evidence=ECO:0000269|PubMed:26245379 332..336 3/3 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 362..383 7/30 (23%)

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