DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa1-R and tkr-2

DIOPT Version :9

Sequence 1:	NP_611241.2	Gene:	CCHa1-R / 37004	FlyBaseID:	FBgn0050106	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_500930.1	Gene:	tkr-2 / 183595	WormBaseID:	WBGene00016761	Length:	391	Species:	Caenorhabditis elegans

Alignment Length:	376	Identity:	98/376 - (26%)
Similarity:	177/376 - (47%)	Gaps:	47/376 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TALPPMPNVTETLWDLAMVVSQSTQWPLLDTGSSENFSELVTTETPYVPYGRRPETYIVP----- 85
            |..|..|::.|  .||.:...:.....|::......:.::..|...|..:  .|..::.|
Worm     2 TTCPLPPSLDE--MDLRLAADKVLNGSLINCTFQSFYDQMYQTHGVYFIF--EPTPFVHPIVSQI 62

  Fly    86 ---ILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVIITTVPLASTVYTVEY- 146
               |||.|...:.::||.|::.:.|..||||:|.|.|:.:||:||     .::.:.:|.::..|
Worm    63 FYGILFTLTIFLALMGNFTVMWIILYHRQMRSVTNYYLFNLAVAD-----ASISVFNTGFSWSYN 122

  Fly   147 ----WPYGSFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRATRMTLATA 207
                |.:|||.|.::..|....|..||||:..:|.:||:||:.||:|       |...|.|:...
Worm   123 YYYVWKFGSFYCRINNLMGITPICASVFTMIVMSIERYYAIIHPLKK-------RPGRRSTVTII 180

  Fly   208 VSIWLLAILCGLPALIGSNLK----HLGINEKSIVIC----YPYPEE--WGINYAKSMVLLHFLV 262
            :.||.:|.|.|:||.:.|.:.    :.|.......:|    ||...|  .|..|...::    .|
Worm   181 IMIWFMAFLFGVPAFLASKVDVYYFYDGYTLYENPLCLADNYPGGNESLLGQVYNNGLI----TV 241

  Fly   263 YYAIPLVVIAVFYVLIALHLMYSASVPGEIQGAVRQVRARRKVAVTVLAFVVIFGICFLPYHVFF 327
            .|.:||.:::..|..:.:.|....:| |:::.| :.|.|::|.::.:...|.||.|.:.||:.::
Worm   242 QYILPLCILSAAYYRVGVELRKDKTV-GDVRHA-KSVAAKKKASIMLAVVVFIFMIVWFPYNAYY 304

  Fly   328 LWFYFWPTAQDDYNAFWHVLRIVAYCMSFANSCANPVALYFVSGAFRKHFN 378
            |..:......:...:.:..:.|  |.:..:::..|||..||::..||..|:
Worm   305 LTLHLVEPIGNKMLSLYIYINI--YWLGMSSTVFNPVIYYFMNKRFRVGFH 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tm_4	88..>188	CDD:304433	36/104 (35%)
CCHa1-R	NP_611241.2	7tm_1	98..364	CDD:278431	76/280 (27%)
tkr-2	NP_500930.1	7tmA_TACR	62..352	CDD:320512	86/309 (28%)
		TM helix 1	64..88	CDD:320512	7/23 (30%)
		TM helix 2	97..119	CDD:320512	7/26 (27%)
		TM helix 3	135..157	CDD:320512	6/21 (29%)
		TM helix 4	178..194	CDD:320512	5/15 (33%)
		TM helix 5	232..255	CDD:320512	5/26 (19%)
		TM helix 6	280..305	CDD:320512	7/24 (29%)
		TM helix 7	320..345	CDD:320512	7/26 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810