DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa1-R and Grpr

DIOPT Version :9

Sequence 1:	NP_611241.2	Gene:	CCHa1-R / 37004	FlyBaseID:	FBgn0050106	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_032203.1	Gene:	Grpr / 14829	MGIID:	95836	Length:	384	Species:	Mus musculus

Alignment Length:	355	Identity:	132/355 - (37%)
Similarity:	209/355 - (58%)	Gaps:	22/355 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 YIVPILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVIITTVPLASTVYTVEY 146
            |::|.::.||.|:|::||.|||.:|.:|:.||||||.:|.||||.|||:::|..|:.::.|..:.
Mouse    42 YVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADR 106

  Fly   147 WPYGSFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRATRMTLATAVSIW 211
            |.:|...|.|..|::..|:|||||||||||.|||.|||.|:....:|     |.......|..||
Mouse   107 WLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASH-----ALMKICLKAALIW 166

  Fly   212 LLAILCGLPALIGSNLK--HLGINEKSIVICYPYPEEWGINYAKSMVLLHFLVYYAIPLVVIAVF 274
            ::::|..:|..:.|:|.  |:....::.:.|.|||....: :.|...:..|||:|.|||.:|:|:
Mouse   167 IVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNEL-HPKIHSMASFLVFYVIPLAIISVY 230

  Fly   275 YVLIALHLMYSA-SVPGEIQGAV---RQVRARRKVAVTVLAFVVIFGICFLPYHVFFLW--FYFW 333
            |..||.:|:.|| ::|  ::|.:   :|:.:|:::|.|||.||.:|..|:||.||.:|:  :::
Mouse   231 YYFIARNLIQSAYNLP--VEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHY- 292

  Fly   334 PTAQDDYNAFWHVLRIVAYCMSFANSCANPVALYFVSGAFRKHFNRYLFC--RGASGRRKKRGQH 396
              ::.|.:....|..|.|..::|.|||.||.|||.:|.:|||.||..|.|  .|...|....|:
Mouse   293 --SEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLMNRSHSTGR- 354

  Fly   397 DTFCMHRDTSLTSTASKRFQSRHSCYQSTI 426
            .|.||....|...:|:....:|:.|::..:
Mouse   355 STTCMTSFKSTNPSATFSLINRNICHEGYV 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tm_4	88..>188	CDD:304433	52/99 (53%)
CCHa1-R	NP_611241.2	7tm_1	98..364	CDD:278431	104/273 (38%)
Grpr	NP_032203.1	7tm_1	58..321	CDD:278431	104/273 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I3534
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3485
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153238at2759
OrthoFinder	1	1.000	-	-		FOG0001846
OrthoInspector	1	1.000	-	-		mtm8893
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45695
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4897
SonicParanoid	1	1.000	-	-		X1046
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100