DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa1-R and GPR151

DIOPT Version :9

Sequence 1:	NP_611241.2	Gene:	CCHa1-R / 37004	FlyBaseID:	FBgn0050106	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_919227.2	Gene:	GPR151 / 134391	HGNCID:	23624	Length:	419	Species:	Homo sapiens

Alignment Length:	313	Identity:	78/313 - (24%)
Similarity:	140/313 - (44%)	Gaps:	33/313 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 YVPYGRRPETYIVPILFALIFVVGVLGNGTLIVVFL--SVRQMRNVPNTYILSLALADLLVIITT 134
            |:|...:....|:|.|...:.:||.:||..:|.:.|  :.:...::.::.||:|:||||.:::.:
Human    27 YLPSDSQDWRTIIPALLVAVCLVGFVGNLCVIGILLHNAWKGKPSMIHSLILNLSLADLSLLLFS 91

  Fly   135 VPLASTVYTVEYWPYGSFLCSLSEFMKDVSIGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRA 199
            .|:.:|.|:...|..|.|:|..|::.....:.....|:..::...:....||.::...|
Human    92 APIRATAYSKSVWDLGWFVCKSSDWFIHTCMAAKSLTIVVVAKVCFMYASDPAKQVSIH------ 150

  Fly   200 TRMTL-ATAVSIWLLAILCGLPALIGSNLKHLGINEKSIVICYPYPEEWGINYAKSMVLLHFLVY 263
             ..|: :..|:||.:|.|..||....|.::|....|..:|......||:...:.|    |:.|:.
Human   151 -NYTIWSVLVAIWTVASLLPLPEWFFSTIRHHEGVEMCLVDVPAVAEEFMSMFGK----LYPLLA 210

  Fly   264 YAIPLVVIAVFYVLIALHLMYSASVPGEIQGAVRQVRARRKVAVTVLAFVVIFGICFLPYHVFFL 328
            :.:|| ..|.||...|.........  :.|....|:|: ::|.|.:|:..:|..:.:||..|.:|
Human   211 FGLPL-FFASFYFWRAYDQCKKRGT--KTQNLRNQIRS-KQVTVMLLSIAIISALLWLPEWVAWL 271

  Fly   329 WFYFW------PTAQDDYNAFWHVLRIVAYCMSFANSCANPVALYFVSGAFRK 375
            |  .|      |.....:.|...||       .|:.|.|||:....:|..||:
Human   272 W--VWHLKAAGPAPPQGFIALSQVL-------MFSISSANPLIFLVMSEEFRE 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tm_4	88..>188	CDD:304433	24/101 (24%)
CCHa1-R	NP_611241.2	7tm_1	98..364	CDD:278431	67/274 (24%)
GPR151	NP_919227.2	7tmA_GPR151	38..317	CDD:320133	76/302 (25%)
		TM helix 1	38..64	CDD:320133	9/25 (36%)
		TM helix 2	73..98	CDD:320133	8/24 (33%)
		TM helix 3	110..140	CDD:320133	3/29 (10%)
		TM helix 4	153..174	CDD:320133	8/20 (40%)
		TM helix 5	199..228	CDD:320133	9/33 (27%)
		TM helix 6	243..273	CDD:320133	10/32 (31%)
		TM helix 7	285..310	CDD:320133	8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..419
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7621
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45695
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960