DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa1-R and MRGPRX3

DIOPT Version :9

Sequence 1:	NP_611241.2	Gene:	CCHa1-R / 37004	FlyBaseID:	FBgn0050106	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001357393.1	Gene:	MRGPRX3 / 117195	HGNCID:	17980	Length:	322	Species:	Homo sapiens

Alignment Length:	340	Identity:	83/340 - (24%)
Similarity:	138/340 - (40%)	Gaps:	95/340 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 TPYVPYGRRPET--YIVPILF----ALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADL 128
            |...|...|.||  |...:.|    .::.:|.:.|| .:::..|..|..||..:.|||:|..||.
Human    10 TELTPINGREETPCYKQTLSFTGLTCIVSLVALTGN-AVVLWLLGCRMRRNAVSIYILNLVAADF 73

  Fly   129 LVIITTV------------PLASTVYTVEYWPYGSFLCSLSEFMKDVSIGVSVFTLTALSGDRYF 181
            |.:...:            |::..:..|..:||              .||:|:  |:|:|.:|..
Human    74 LFLSGHIICSPLRLINIRHPISKILSPVMTFPY--------------FIGLSM--LSAISTERCL 122

  Fly   182 AIVDPLRKFHAHGGGRRATRMTLATAVSIWLLAILCGLPALIGSNLKHLGINEKSIVICYPYPEE 246
            :|:.|: .:|.    ||...::....|.:|.|::|                  :||:       |
Human   123 SILWPI-WYHC----RRPRYLSSVMCVLLWALSLL------------------RSIL-------E 157

  Fly   247 W--------GIN----YAKSMVLLHFLVYYAIPLVVIAVFYVLIALHLMYSASVPGEIQGAVRQV 299
            |        |.|    .....:.:.:||:..:  |:.....||:...|..|..:|
Human   158 WMFCDFLFSGANSVWCETSDFITIAWLVFLCV--VLCGSSLVLLVRILCGSRKMP---------- 210

  Fly   300 RARRKVAVTVLAFVVIFGICFLPYHVFFLWFYFWPTAQDDYNAFWHVLRIVAYCMSFANSCANPV 364
              ..::.||:|..|::|.:|.||:.:  .|..|.....|....|.|| .:|:..:|..||.|||:
Human   211 --LTRLYVTILLTVLVFLLCGLPFGI--QWALFSRIHLDWKVLFCHV-HLVSIFLSALNSSANPI 270

  Fly   365 ALYFVSGAFRKHFNR 379
             :||..|:||:..||
Human   271 -IYFFVGSFRQRQNR 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tm_4	88..>188	CDD:304433	28/115 (24%)
CCHa1-R	NP_611241.2	7tm_1	98..364	CDD:278431	67/289 (23%)
MRGPRX3	NP_001357393.1	7tmA_MrgprX-like	28..299	CDD:320234	77/322 (24%)
		TM helix 1	29..55	CDD:320234	5/26 (19%)
		TM helix 2	61..87	CDD:320234	7/25 (28%)
		TM helix 3	97..125	CDD:320234	10/43 (23%)
		TM helix 4	137..157	CDD:320234	6/44 (14%)
		TM helix 5	180..205	CDD:320234	6/26 (23%)
		TM helix 6	209..239	CDD:320234	10/43 (23%)
		TM helix 7	251..276	CDD:320234	11/26 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910