DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa1-R and MRGPRF

DIOPT Version :9

Sequence 1:	NP_611241.2	Gene:	CCHa1-R / 37004	FlyBaseID:	FBgn0050106	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_001091985.1	Gene:	MRGPRF / 116535	HGNCID:	24828	Length:	343	Species:	Homo sapiens

Alignment Length:	322	Identity:	73/322 - (22%)
Similarity:	135/322 - (41%)	Gaps:	97/322 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 PETYIVPILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVIITTVPLASTVYT 143
            |...::..:|.|:.:.|::||| |::.|......||..:.|.|.||.||:..:     .:..|::
Human    42 PPPAVMNYIFLLLCLCGLVGNG-LVLWFFGFSIKRNPFSIYFLHLASADVGYL-----FSKAVFS 100

  Fly   144 VEYWPYGSFLCSLSEFMKDVS--IGVSVF-----TLTALSGDRYFAIVDPLRKFHAHGGGRRATR 201
            :  ...|.||.:.:::::.|.  :|:.:|     .|.|:|.:|..:::     |.|....||..|
Human   101 I--LNTGGFLGTFADYIRSVCRVLGLCMFLTGVSLLPAVSAERCASVI-----FPAWYWRRRPKR 158

  Fly   202 MTLATAVSIWLLAIL--------C-----GLPALIGSNLKHLGINEKSIVICYPYPEEWGINYAK 253
            ::......:|:|::|        |     |.|   |:..:|:.|
Human   159 LSAVVCALLWVLSLLVTCLHNYFCVFLGRGAP---GAACRHMDI--------------------- 199

  Fly   254 SMVLLHFLVYYAIPLVVIAVFYVLIALHLMYSASVPGEIQGAVRQVRARR-----KVAVTVLAFV 313
            .:.:|.||:  ..||:|:..  :.:.||:               :.||||     |:...:||.|
Human   200 FLGILLFLL--CCPLMVLPC--LALILHV---------------ECRARRRQRSAKLNHVILAMV 245

  Fly   314 VIFGICFLPYHVFFLWFYFW----PTAQDDYNAFWHVLRIVAYCMSFANSCANPVALYFVSG 371
            .:|.:..:  ::...||.||    |....:|        :...|:.. ||.|.|: :||::|
Human   246 SVFLVSSI--YLGIDWFLFWVFQIPAPFPEY--------VTDLCICI-NSSAKPI-VYFLAG 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tm_4	88..>188	CDD:304433	27/106 (25%)
CCHa1-R	NP_611241.2	7tm_1	98..364	CDD:278431	65/294 (22%)
MRGPRF	NP_001091985.1	7tmA_MrgprF	45..318	CDD:320237	72/319 (23%)
		TM helix 1	46..72	CDD:320237	8/26 (31%)
		TM helix 2	78..104	CDD:320237	7/32 (22%)
		TM helix 3	118..146	CDD:320237	7/27 (26%)
		TM helix 4	158..178	CDD:320237	4/19 (21%)
		TM helix 5	202..227	CDD:320237	8/43 (19%)
		TM helix 6	232..262	CDD:320237	7/31 (23%)
		TM helix 7	270..295	CDD:320237	8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..343
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910