DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCHa1-R and MRGPRD

DIOPT Version :9

Sequence 1:	NP_611241.2	Gene:	CCHa1-R / 37004	FlyBaseID:	FBgn0050106	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_944605.2	Gene:	MRGPRD / 116512	HGNCID:	29626	Length:	321	Species:	Homo sapiens

Alignment Length:	374	Identity:	86/374 - (22%)
Similarity:	160/374 - (42%)	Gaps:	100/374 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 MNIGLDTSGEAPTALPPMPNVTETLWDLAMVVSQSTQWPLLDTGSSENFSELVTTETPYVPYGRR 78
            ||..|::||...:||                                |:|...|..|.|:
Human     1 MNQTLNSSGTVESAL--------------------------------NYSRGSTVHTAYL----- 28

  Fly    79 PETYIVPILFALIFVVGVLGNGTLIVVFLSVRQMRNVPNTYILSLALADLLVIITTVPLASTVYT 143
                ::..|.....:.|:.|| ::::..|..|..||....|||:||.||||.:.:   :|||: :
Human    29 ----VLSSLAMFTCLCGMAGN-SMVIWLLGFRMHRNPFCIYILNLAAADLLFLFS---MASTL-S 84

  Fly   144 VEYWPYGSFLCSLSEFMKDV-----SIGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRATRMT 203
            :|..|..:....:.|.||.:     ::|:|:  |||:|..|..:::.|: .|..|    |...::
Human    85 LETQPLVNTTDKVHELMKRLMYFAYTVGLSL--LTAISTQRCLSVLFPI-WFKCH----RPRHLS 142

  Fly   204 LATAVSIWLLAILC-GLPALIGSNLKHLGINEKSIVICYPYPEEWGINYAKSMVLLHFLVYYAIP 267
            ......:|.|.:|. ||.:...|  |.|..||..   |:      .::..::.:::..|.    |
Human   143 AWVCGLLWTLCLLMNGLTSSFCS--KFLKFNEDR---CF------RVDMVQAALIMGVLT----P 192

  Fly   268 LVVIAVFYVLIALHLMYSASVPGEIQGAVRQVRARRKVAVTVLAFVVIFGICFLPYHVFFLWF-Y 331
            ::.::...:.:.:.           :.:.:..|...::.|.|||.|::|.||.||..::  || .
Human   193 VMTLSSLTLFVWVR-----------RSSQQWRRQPTRLFVVVLASVLVFLICSLPLSIY--WFVL 244

  Fly   332 FWPTAQDDYNAFWHVLRIVAYCM----SFANSCANPVALYFVSGAFRKH 376
            :|.:...:       ::::.:.:    |..:|.|||| :||:.|:.|.|
Human   245 YWLSLPPE-------MQVLCFSLSRLSSSVSSSANPV-IYFLVGSRRSH 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCHa1-R	NP_611241.2	7tm_4	88..>188	CDD:304433	32/104 (31%)
CCHa1-R	NP_611241.2	7tm_1	98..364	CDD:278431	65/276 (24%)
MRGPRD	NP_944605.2	7tm_1	44..276	CDD:278431	67/279 (24%)
MRGPRD	NP_944605.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..321
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910