DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smurf and Magi3

DIOPT Version :9

Sequence 1:NP_001261061.1 Gene:Smurf / 36999 FlyBaseID:FBgn0029006 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_001152826.1 Gene:Magi3 / 99470 MGIID:1923484 Length:1476 Species:Mus musculus


Alignment Length:999 Identity:195/999 - (19%)
Similarity:292/999 - (29%) Gaps:356/999 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   153 SGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDRPRQPGVVGSSHATSPQQRHN 217
            |.|.|.....|.:.:.||:.||...||.|.:|:::|.||:|.|..||.     ...|.:|:    
Mouse   282 SMDFRNYMMRDENLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRL-----CKKAKAPE---- 337

  Fly   218 THNGNSGDRQAPAG------P----------TRSTTCTNLMNNGHRSRDL------SVTASDERR 260
                :..|.:.|.|      |          .:.|...|.:....|.:.|      |.....||.
Mouse   338 ----DCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQAEIHSAKTDVERA 398

  Fly   261 HSTEILSSVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRP----------TNEPATPT 315
            |.|        .:.|....|....:..|.|.....:..||    .||          .:.||...
Mouse   399 HFT--------RDPSQLKGVLVRASLKKSTMGFGFTIIGG----DRPDEFLQVKNVLKDGPAAQD 451

  Fly   316 SSTTSASVRLHSNDNHVKTPKHQTNGHAPPEST---PTSPTGQQNYVNGNAQNGSTSGNGSGQAA 377
            .......|.:..|.|.|.       ||...:..   ...|..|  |||.....|...        
Mouse   452 GKIAPGDVIVDINGNCVL-------GHTHADVVQMFQLVPVNQ--YVNLTLCRGYPL-------- 499

  Fly   378 QPQSASNGWTQEDAATTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANG----------NVHSP 432
                                      |..|:.|    :....:.||..||          |....
Mouse   500 --------------------------PDDSEDP----VVDIVAATPVINGQSLTKGETCMNTQDF 534

  Fly   433 NANSTPAGSGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRY 497
            ...:......|.|....|          |.|..|...|:.:|:|                    .
Mouse   535 KLGAMVLDQNGKSGQILA----------SDRLNGPSESSEQRAS--------------------L 569

  Fly   498 ASAAIAAANQAARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLDAIGP 562
            ||:..:.......|.:..|.|:.......        |||      .::....|:|         
Mouse   570 ASSGSSQPELVTIPLIKGPKGFGFAIADS--------PTG------QKVKMILDSQ--------- 611

  Fly   563 LPSGW---EQRKTASGRVYFVDHNNRT--------TQFTDPRLSGSILQMIRRGTVPPTSAANAG 616
                |   .|:......:|..:..|.|        .||  |..:...|.::|.|...||..|...
Mouse   612 ----WCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQF--PVGADVPLLILRGGPCSPTKTAKTK 670

  Fly   617 TPAP-------------PSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPH----------- 657
            |...             |...|..||...:..|:..|:.....:.......||:           
Mouse   671 TDTKENSGSLETINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQ 735

  Fly   658 ------RIV----PDLPQGLLEGADLLPKYRRDLVGKLRALR------------------TELQT 694
                  |::    ||  |.:..|| ::|....:..|:|||..                  .:|.|
Mouse   736 ESGFGFRVLGGDGPD--QSIYIGA-IIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMT 797

  Fly   695 MQPQSGHCRLEVSRNEIF-------EESYRLIMKMRAKDM-RKRLMVKFKGEEGLDYGGVAREWL 751
            ...::||..|.| |.:||       :||::...:..:..: |..|..:...:|..|        :
Mouse   798 TAARNGHVLLTV-RRKIFYGEKQPEDESHQAFSQNGSPRLNRAELPTRSAPQEAYD--------V 853

  Fly   752 HLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLD--GGFT 814
            .|..:|  |..:|..      ..|.:..|..||.|      |.:||     |..|...|  ||  
Mouse   854 TLQRKE--NEGFGFV------ILTSKSKPPPGVIP------HKIGR-----VIDGSPADRCGG-- 897

  Fly   815 TPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHELKPGGAS 879
                       :.:||        |.|..     |...|::  .|.:|      :|..:|..|.:
Mouse   898 -----------LKVGD--------HISAV-----NGQSIVD--LSHDN------IVQLIKDAGVT 930

  Fly   880 IPVTEENKREYVKLYVNYRFMRG------IEQQFLALQ-KGFCELIPSHLLRPFDERELELVIG- 936
            :.:|...:.|:          .|      ..:|..||| :...:...:|:  |.|...||..|| 
Mouse   931 VTLTVVAEEEH----------HGPPSGTNSARQSPALQHRPMGQAQANHI--PGDRIALEGEIGR 983

  Fly   937 GISSIDVNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQ------GF 995
            .:.|...:.|.::   ||.....|.|:   .||.|..::.        .|...|.|:      ||
Mouse   984 DVCSSYRHSWSDH---KHLAQPDTAVI---SVVGSRHNQS--------LGCYPVELERGPRGFGF 1034

  Fly   996 RALQGSTGAVGPRLFTIHLTADVP 1019
            ....|....:|  ||.:.|..|.|
Mouse  1035 SLRGGKEYNMG--LFILRLAEDGP 1056

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmurfNP_001261061.1 C2_Smurf-like 14..135 CDD:176028
WW 169..198 CDD:278809 13/28 (46%)
WW 514..546 CDD:197736 5/31 (16%)
WW 562..594 CDD:197736 8/42 (19%)
HECTc 702..1058 CDD:238033 74/342 (22%)
HECTc 726..1058 CDD:214523 67/311 (22%)
Magi3NP_001152826.1 Interaction with ADRB1 and TGFA. /evidence=ECO:0000269|PubMed:15652357 18..108
PDZ_signaling 24..103 CDD:238492
NK 125..>199 CDD:302627
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 184..266
WW 297..329 CDD:197736 14/31 (45%)
WW 345..375 CDD:238122 5/29 (17%)
Interaction with PTEN. /evidence=ECO:0000250 413..495 19/94 (20%)
PDZ 416..496 CDD:214570 19/92 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 551..575 9/53 (17%)
PDZ 578..659 CDD:214570 18/109 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 664..691 4/26 (15%)
PDZ 729..812 CDD:214570 18/86 (21%)
Interaction with ADGRB1. /evidence=ECO:0000250 729..811 17/85 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..844 4/25 (16%)
PDZ_signaling 851..936 CDD:238492 30/145 (21%)
Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250 852..939 30/147 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..966 6/36 (17%)
PDZ_signaling 1023..1101 CDD:238492 11/36 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1109..1151
MIP-T3 <1166..>1431 CDD:287245
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1168..1476
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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