DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and AREL1

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001034568.1	Gene:	AREL1 / 9870	HGNCID:	20363	Length:	823	Species:	Homo sapiens

Alignment Length:	398	Identity:	130/398 - (32%)
Similarity:	194/398 - (48%)	Gaps:	38/398 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   684 KLRALRTELQTMQPQSGHCR--LEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGV 746
            |:...:.||:.:..:..|.:  |:|||:.:.|.|.:........|..|...|.|:.||.||:||.
Human   442 KVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGP 506

  Fly   747 AREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDH--LSYFHFVGRTLGIAVFHGHCL 809
            .|||..|:.:.:.:....||....|::..| ::|:.. .|.|  |..:.|.||.:|..::....
Human   507 RREWFELICKALFDTTNQLFTRFSDNNQAL-VHPNPN-RPAHLRLKMYEFAGRLVGKCLYESSL- 568

  Fly   810 DGG---------FTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVEN-NS 864
             ||         ||..|..|::...:.....|..||:.::|....:.:|....:|..|:.|. |.
Human   569 -GGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEMELVFAEEKYNK 632

  Fly   865 FGAL-VVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDE 928
            .|.| .|.||..|||..|||..||..|:.|...||....::::.....||..||:|.:||..|||
Human   633 SGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDE 697

  Fly   929 RELELVIGGISSIDVNDWRNNTRLK----HCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSR 989
            .||||::.|...|.|:|::.:..:.    |...:..:  |||.||.|.:.|..||||||.||||:
Human   698 NELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMR--WFWTVVSSLTQEELARLLQFTTGSSQ 760

  Fly   990 VPLQGFRALQGSTGAVGPRLFTIHLTADVPTQN-LPKAHTCFNRIDLPPYETYQLLCDKLTQAVE 1053
            :|..||.||..|...:.           .||.: ||.||||||::.||.|::|:.:...|..|:.
Human   761 LPPGGFAALCPSFQIIA-----------APTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAIS 814

  Fly  1054 ETC-GFAV 1060
            |.| ||.:
Human   815 EGCEGFGM 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033	124/376 (33%)
		HECTc	726..1058	CDD:214523	118/350 (34%)
AREL1	NP_001034568.1	Filamin	52..158
		Filamin	56..154	CDD:395505
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..345
		Interaction with SOCS2. /evidence=ECO:0000269\|PubMed:31578312	483..789		105/322 (33%)
		HECTc	486..820	CDD:214523	118/350 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810