DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and MAGI2

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_016868329.1	Gene:	MAGI2 / 9863	HGNCID:	18957	Length:	1540	Species:	Homo sapiens

Alignment Length:	523	Identity:	111/523 - (21%)
Similarity:	160/523 - (30%)	Gaps:	159/523 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 GKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLHSNDNHVKT 334
            |.||..  .|......|||....|.|.......|.:  .||  ||.:..|...|.  :...|.|.
Human    35 GAENGQ--FPYLGEVKPGKVAYESGSKLVSEELLLE--VNE--TPVAGLTIRDVL--AVIKHCKD 91

  Fly   335 P---KHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTS 396
            |   |....|....:..       ::|:|...|.||..     ...|.....|.:.:      |.
Human    92 PLRLKCVKQGGIVDKDL-------RHYLNLRFQKGSVD-----HELQQIIRDNLYLR------TV 138

  Fly   397 PSTTTSPPRHSQSPPTPNI------------------------------SPPASVTPSANGNVHS 431
            | .||.|.:..:.|....|                              .|||...|........
Human   139 P-CTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYEDNYYGTPKPPAEPAPLLLNVTDQ 202

  Fly   432 PNANSTPAGSGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNG-----------GTS 485
            ....:||:..|...|:.:.:     :..::|.:..||....|....|  ||           ..|
Human   203 ILPGATPSAEGKRKRNKSVS-----NMEKASIEPPEEEEEERPVVNG--NGVVVTPESSEHEDKS 260

  Fly   486 GGGGGGGSGQRYASAAIAAANQAARPFLD--------------LPPGYEMRTTQQGQVYFYHIPT 536
            .|..|....|.|.:...:...:......|              ||..:||..|::|:|||....|
Human   261 AGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYTEKGEVYFIDHNT 325

  Fly   537 GVSTWHDPRIPRDFDTQHLTLDAIGPLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQM 601
            ..::|.|||:.:.........:  ..||.|||:........|:|||.||.|||.:|.|...  :.
Human   326 KTTSWLDPRLAKKAKPPEECKE--NELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAK--RK 386

  Fly   602 IRRGTVPPTSAANAGT-----------------PAPPSATP-ATPSAAAAV--------PPQATP 640
            :::..:|.|   ..||                 |.|.|..| |.|..:.:|        .|...|
Human   387 LQQHNMPHT---ELGTKPLQAPGFRVDSSSWTLPRPKSIRPRAAPERSRSVNDLSYYQRDPAGRP 448

  Fly   641 -----------ASNATPTTLTTTTNPPH--------------------RIVPDLP---QGLLEGA 671
                       ||....|.|:||....:                    .::||.|   .|.:|..
Human   449 WLFEKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETG 513

  Fly   672 DLL 674
            |::
Human   514 DVI 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	14/45 (31%)
		WW	562..594	CDD:197736	15/31 (48%)
		HECTc	702..1058	CDD:238033
		HECTc	726..1058	CDD:214523
MAGI2	XP_016868329.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900