DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and Wwtr1

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001161753.1	Gene:	Wwtr1 / 97064	MGIID:	1917649	Length:	452	Species:	Mus musculus

Alignment Length:	468	Identity:	95/468 - (20%)
Similarity:	148/468 - (31%)	Gaps:	161/468 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   418 PASVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNG 482
            |.|.....:...||  ..|:...|||        .||       .|..|.....|..||..:...
Mouse   106 PESFFKEPDSGSHS--RQSSTDSSGG--------HPG-------PRLAGGAQHVRSHSSPASLQL 153

  Fly   483 GTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIP 547
            || |.|..||..|::|                       ...||.    |.:
Mouse   154 GT-GAGAAGGPAQQHA-----------------------HLRQQS----YDV------------- 177

  Fly   548 RDFDTQHLTLDAIGPLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSA 612
                |..|      |||.|||...||:|:.||::|..:.|.:.|||   .::..       |.:.
Mouse   178 ----TDEL------PLPPGWEMTFTATGQRYFLNHIEKITTWQDPR---KVMNQ-------PLNH 222

  Fly   613 ANAGTPAPPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKY 677
            .|.   .|...:.:.|..:.||.......::.....:.|:.:|.:....:.|.||:...:.|...
Mouse   223 VNL---HPSITSTSVPQRSMAVSQPNLAMNHQHQQVVATSLSPQNHPTQNQPTGLMSVPNALTTQ 284

  Fly   678 RRDLVGKLRALRTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKM--------------RAKDMR 728
            ::. ..|||..|.:::..       |:.:.:.|:..:...|..::              .:.|||
Mouse   285 QQQ-QQKLRLQRIQMERE-------RIRMRQEELMRQEAALCRQLPMETETMAPVNTPAMSTDMR 341

  Fly   729 KRLMVKFKGEEGLDYGGVAREWLHLLSREM-LNPQYGLFQYS----RDDHYTLQINPDSG----- 783
            .   |.....:....||...      |||. .:...||..||    .:|..:.....|:|
Mouse   342 S---VTNSSSDPFLNGGPYH------SREQSTDSGLGLGCYSVPTTPEDFLSNMDEMDTGENSGQ 397

  Fly   784 ----VNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEG---------VD 835
                |||....:..|:           .||.|            ..:.||.:|.         |:
Mouse   398 TPMTVNPQQTRFPDFL-----------DCLPG------------TNVDLGTLESEDLIPLFNDVE 439

  Fly   836 PDLHRS---LTWM 845
            ..|::|   |||:
Mouse   440 SALNKSEPFLTWL 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	3/31 (10%)
		WW	562..594	CDD:197736	15/31 (48%)
		HECTc	702..1058	CDD:238033	35/184 (19%)
		HECTc	726..1058	CDD:214523	32/146 (22%)
Wwtr1	NP_001161753.1	WW	182..213	CDD:197736	14/30 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810