Protein Alignment Smurf and UBE3C

DIOPT Version :9

• Sequence 1: NP_001261061.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_055486.2
• Gene: UBE3C / 9690
• HGNCID: 16803
• Length: 1083
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 143/520 - (27%)
• Similarity: 234/520 - (45%)
• Gaps: 88/520 - (16%)

  Fly   564 PSGW--EQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPP-TSAANAGTPAPPSATP 625
            |:.|  ||....:.:|         ||...| .|..:.:..|.|.:.| .|..:.|..:||
Human   624 PNHWLSEQEDIKADKV---------TQLYVP-ASRHVWRFRRMGRIGPLQSTLDVGLESPP---- 674

  Fly   626 ATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGK--LRAL 688
                                   |:.:......::.:||       .::|...|..:.:  :.|.
Human   675 -----------------------LSVSEERQLAVLTELP-------FVVPFEERVKIFQRLIYAD 709

  Fly   689 RTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKG-----EEGLDYGGVAR 748
            :.|:|...|......:.:.||.|:|::|..:......|::||:.|....     |.|:|.||:.|
Human   710 KQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFR 774

  Fly   749 EWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSG--VNPDHLSYFHFVGRTLGIAVFHGHCLDG 811
            |:|:.|.:...||..|.|:.:.:.  .|..||.:.  |......:::|:||.||.|::....::.
Human   775 EFLNELLKSGFNPNQGFFKTTNEG--LLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVEL 837

  Fly   812 GFTTPFYKQLLNKPITLGDIE-----GVDPDLHRSLTWM--LESNIS--GIIESTFSVENNSFGA 867
            .|...|..:||.   |..|::     .:||:::::|.::  .|.::.  |:   .|:|.||..|.
Human   838 PFAGFFLSKLLG---TSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGL---NFTVVNNDLGE 896

  Fly   868 LVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELE 932
            ..|.|||.||..||||..|:..|:.|..:||..|.|.|..||.::|...::....||.||::|::
Human   897 AQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQ 961

  Fly   933 LVIGG----ISSIDVNDWRNNTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQ 993
            ::|.|    ||..|:..:.|.:......:...:|  ||:|||.::.|.:.:||:|||..||.||.
Human   962 VLISGAQVPISLEDLKSFTNYSGGYSADHPVIKV--FWRVVEGFTDEEKRKLLKFVTSCSRPPLL 1024

  Fly   994 GFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGF 1058
            ||:.|..:        |.|| ......:.||.|.||.|.:.||.:....||..||..|:|...||
Human  1025 GFKELYPA--------FCIH-NGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGF 1080

  Fly  1059  1058
            Human  1081  1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736	8/31 (26%)
		HECTc	702..1058	CDD:238033	116/375 (31%)
		HECTc	726..1058	CDD:214523	111/351 (32%)
UBE3C	NP_055486.2	Cis-determinant of acceptor ubiquitin-binding	1..60
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40
		IQ	47..64	CDD:197470
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..385
		HECTc	725..1081	CDD:238033	118/375 (31%)
		HECTc	747..1080	CDD:214523	111/351 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810