DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smurf and BAG3

DIOPT Version :10

Sequence 1:NP_523779.1 Gene:Smurf / 36999 FlyBaseID:FBgn0029006 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_004272.2 Gene:BAG3 / 9531 HGNCID:939 Length:575 Species:Homo sapiens


Alignment Length:663 Identity:127/663 - (19%)
Similarity:203/663 - (30%) Gaps:250/663 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   163 DSSEDSLPEGWEER-RTDNGRVYYVNHATKSTQWDRPRQPGVVGSSHATSPQQRHNTHNGNS--G 224
            :...|.||.|||.: ....|..::|:|.:::|.|:.||.|       :..|::..::.||.|  |
Human    16 NGDRDPLPPGWEIKIDPQTGWPFFVDHNSRTTTWNDPRVP-------SEGPKETPSSANGPSREG 73

  Fly   225 DRQAPAGPTRSTTCTNLMNNGH------RSRDLSVTASDE------------------RRHSTEI 265
            .|..||            ..||      |...:.:....|                  :|..||.
Human    74 SRLPPA------------REGHPVYPQLRPGYIPIPVLHEGAENRQVHPFHVYPQPGMQRFRTEA 126

  Fly   266 LSSVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRP--TNEPATPTSSTTSASVRLHSN 328
            .::..:.:.||...:..||.|.|:.....:::|........|  :..||....|::|:|..|.|:
Human   127 AAAAPQRSQSPLRGMPETTQPDKQCGQVAAAAAAQPPASHGPERSQSPAASDCSSSSSSASLPSS 191

  Fly   329 DNHVKTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAAT 393
            .      :.....|..|....:.|...:.             |.:..||||       :...|..
Human   192 G------RSSLGSHQLPRGYISIPVIHEQ-------------NVTRPAAQP-------SFHQAQK 230

  Fly   394 TTSPS-----TTTSPPRHS------QSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRS 447
            |..|:     .|..|..|.      :..|....||..|....|:....||..:|||..|....|.
Human   231 THYPAQQGEYQTHQPVYHKIQGDDWEPRPLRAASPFRSSVQGASSREGSPARSSTPLHSPSPIRV 295

  Fly   448 YTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPF 512
            :|..   .|.|:..:.:  |.:...:..::.....|..|.                         
Human   296 HTVV---DRPQQPMTHR--ETAPVSQPENKPESKPGPVGP------------------------- 330

  Fly   513 LDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLDAIGPLPSGWEQRKTASGRV 577
             :||||              |||..|       |.::.|::.::...  |.||...:.|      
Human   331 -ELPPG--------------HIPIQV-------IRKEVDSKPVSQKP--PPPSEKVEVK------ 365

  Fly   578 YFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAP-----PSATPATPSAAAA---V 634
                                         |||     |..|.|     |||.|::|.:.|.   .
Human   366 -----------------------------VPP-----APVPCPPPSPGPSAVPSSPKSVATEERA 396

  Fly   635 PPQATPASNATPTTLTTTTNPPH------RIVPDLPQGLLEGAD------------LLPKY---- 677
            .|...||....|........|.|      ..:.:..|||.:..|            ::.:|    
Human   397 APSTAPAEATPPKPGEAEAPPKHPGVLKVEAILEKVQGLEQAVDNFEGKKTDKKYLMIEEYLTKE 461

  Fly   678 ------------------RRDLVGKLRALRTELQ-------------TMQPQSGHCRLEVSRNEI 711
                              |||.|.|::.:..:|:             .:||.:    ||.     
Human   462 LLALDSVDPEGRADVRQARRDGVRKVQTILEKLEQKAIDVPGQVQVYELQPSN----LEA----- 517

  Fly   712 FEESYRLIMKMRA 724
             ::..:.||:|.|
Human   518 -DQPLQAIMEMGA 529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmurfNP_523779.1 C2_Smurf-like 14..135 CDD:176028
PRP40 155..>283 CDD:227435 31/146 (21%)
WW 169..198 CDD:459800 10/29 (34%)
WW 514..546 CDD:197736 8/31 (26%)
WW 562..594 CDD:197736 4/31 (13%)
HECTc 702..1058 CDD:238033 6/23 (26%)
BAG3NP_004272.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..92 25/94 (27%)
WW 21..53 CDD:197736 10/31 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 123..200 17/82 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..421 53/274 (19%)
PHA03247 <257..417 CDD:223021 48/253 (19%)
BAG 421..498 CDD:214591 11/76 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..575
Blue background indicates that the domain is not in the aligned region.

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