DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smurf and BAG3

DIOPT Version :9

Sequence 1:NP_001261061.1 Gene:Smurf / 36999 FlyBaseID:FBgn0029006 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_004272.2 Gene:BAG3 / 9531 HGNCID:939 Length:575 Species:Homo sapiens


Alignment Length:663 Identity:127/663 - (19%)
Similarity:203/663 - (30%) Gaps:250/663 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   163 DSSEDSLPEGWEER-RTDNGRVYYVNHATKSTQWDRPRQPGVVGSSHATSPQQRHNTHNGNS--G 224
            :...|.||.|||.: ....|..::|:|.:::|.|:.||.|       :..|::..::.||.|  |
Human    16 NGDRDPLPPGWEIKIDPQTGWPFFVDHNSRTTTWNDPRVP-------SEGPKETPSSANGPSREG 73

  Fly   225 DRQAPAGPTRSTTCTNLMNNGH------RSRDLSVTASDE------------------RRHSTEI 265
            .|..||            ..||      |...:.:....|                  :|..||.
Human    74 SRLPPA------------REGHPVYPQLRPGYIPIPVLHEGAENRQVHPFHVYPQPGMQRFRTEA 126

  Fly   266 LSSVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRP--TNEPATPTSSTTSASVRLHSN 328
            .::..:.:.||...:..||.|.|:.....:::|........|  :..||....|::|:|..|.|:
Human   127 AAAAPQRSQSPLRGMPETTQPDKQCGQVAAAAAAQPPASHGPERSQSPAASDCSSSSSSASLPSS 191

  Fly   329 DNHVKTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAAT 393
            .      :.....|..|....:.|...:.             |.:..||||       :...|..
Human   192 G------RSSLGSHQLPRGYISIPVIHEQ-------------NVTRPAAQP-------SFHQAQK 230

  Fly   394 TTSPS-----TTTSPPRHS------QSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRS 447
            |..|:     .|..|..|.      :..|....||..|....|:....||..:|||..|....|.
Human   231 THYPAQQGEYQTHQPVYHKIQGDDWEPRPLRAASPFRSSVQGASSREGSPARSSTPLHSPSPIRV 295

  Fly   448 YTAATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPF 512
            :|..   .|.|:..:.:  |.:...:..::.....|..|.                         
Human   296 HTVV---DRPQQPMTHR--ETAPVSQPENKPESKPGPVGP------------------------- 330

  Fly   513 LDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLDAIGPLPSGWEQRKTASGRV 577
             :||||              |||..|       |.::.|::.::...  |.||...:.|      
Human   331 -ELPPG--------------HIPIQV-------IRKEVDSKPVSQKP--PPPSEKVEVK------ 365

  Fly   578 YFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAP-----PSATPATPSAAAA---V 634
                                         |||     |..|.|     |||.|::|.:.|.   .
Human   366 -----------------------------VPP-----APVPCPPPSPGPSAVPSSPKSVATEERA 396

  Fly   635 PPQATPASNATPTTLTTTTNPPH------RIVPDLPQGLLEGAD------------LLPKY---- 677
            .|...||....|........|.|      ..:.:..|||.:..|            ::.:|    
Human   397 APSTAPAEATPPKPGEAEAPPKHPGVLKVEAILEKVQGLEQAVDNFEGKKTDKKYLMIEEYLTKE 461

  Fly   678 ------------------RRDLVGKLRALRTELQ-------------TMQPQSGHCRLEVSRNEI 711
                              |||.|.|::.:..:|:             .:||.:    ||.     
Human   462 LLALDSVDPEGRADVRQARRDGVRKVQTILEKLEQKAIDVPGQVQVYELQPSN----LEA----- 517

  Fly   712 FEESYRLIMKMRA 724
             ::..:.||:|.|
Human   518 -DQPLQAIMEMGA 529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmurfNP_001261061.1 C2_Smurf-like 14..135 CDD:176028
WW 169..198 CDD:278809 10/29 (34%)
WW 514..546 CDD:197736 8/31 (26%)
WW 562..594 CDD:197736 4/31 (13%)
HECTc 702..1058 CDD:238033 6/23 (26%)
HECTc 726..1058 CDD:214523
BAG3NP_004272.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..92 25/94 (27%)
WW 21..53 CDD:197736 10/31 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 123..200 17/82 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..421 53/274 (19%)
BAG 421..498 CDD:214591 11/76 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..575
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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