DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and TRIP12

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_024308991.1	Gene:	TRIP12 / 9320	HGNCID:	12306	Length:	2092	Species:	Homo sapiens

Alignment Length:	1320	Identity:	270/1320 - (20%)
Similarity:	447/1320 - (33%)	Gaps:	391/1320 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ARNLARKDLFRLPDPFAKVQVDGTGQVYS---------------TEISKSSLDPKWNAHYDLF-L 70
            ||.:.||     |:|.|.....|    ||               .|::||.:...:...|::: .
Human   869 ARAIQRK-----PNPLANSNTSG----YSESKKDDARAQLMKEDPELAKSFIKTLFGVLYEVYSS 924

  Fly    71 GIGDAITITVWNQRKIHKGSGFLGCVR-----IPAFNIQSLKGAGFQRLDLGKLSPDDDELVRGQ 130
            ..|.|:.         ||      |:|     |...:.:.||       |:.|     :..|...
Human   925 SAGPAVR---------HK------CLRAILRIIYFADAELLK-------DVLK-----NHAVSSH 962

  Fly   131 IIISLLSKDGPSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQW 195
            |...|.|:|       |.||     |......:.....||:.:.......|.::.|.|..:|
Human   963 IASMLSSQD-------LKIV-----VGALQMAEILMQKLPDIFSVYFRREGVMHQVKHLAES--- 1012

  Fly   196 DRPRQPGVVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNG----HRSRDLSVTAS 256
                      .|..|||.:.....:|:.|...:.:..|.:.......:.|    ..|||.|:..|
Human  1013 ----------ESLLTSPPKACTNGSGSMGSTTSVSSGTATAATHAAADLGSPSLQHSRDDSLDLS 1067

  Fly   257 DERRHSTEILSSVGKENTSPTTP---------------VSATTTPGKKTS--SSNSSSAGGRTLE 304
            .:.|.| ::|.........|..|               .|.|||...|:|  :|.:....||...
Human  1068 PQGRLS-DVLKRKRLPKRGPRRPKYSPPRDDDKVDNQAKSPTTTQSPKSSFLASLNPKTWGRLST 1131

  Fly   305 QRPTN--EPATPTSST---TSASVRLHSNDNH-----VKTPKHQ----------TNGHAPPEST- 348
            |..:|  |||.....:   .:||....||:..     :|...|:          .:|..|..:.
Human  1132 QSNSNNIEPARTAGGSGLARAASKDTISNNREKIKGWIKEQAHKFVERYFSSENMDGSNPALNVL 1196

  Fly   349 --PTSPTGQQN-YVNGNAQ-----NGSTSGNGSGQAAQPQSASNGWTQEDAATTTSPSTTTSPPR 405
              ..:.|.|.| .|:|.|:     ....|   ....:..:...:|:.::.....||.|...:..|
Human  1197 QRLCAATEQLNLQVDGGAECLVEIRSIVS---ESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSR 1258

  Fly   406 HSQ---------SPPTPNISPPASVTPSANGN----VHSPN------------ANSTPAGSGGGS 445
            ..:         |.|.|...|...|.|..|..    ||..|            .:..|:|:|.|.
Human  1259 EIRLKRFLHVFFSSPLPGEEPIGRVEPVGNAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGTGG 1323

  Fly   446 RSYTAATPGQRSQRRSSRQQGEESSTRRRSSRG------------------TRNGG----TSGGG 488
            |...|.......|.:...|:..:.:..::...|                  .|..|    .....
Human  1324 RGSQALKFFNTHQLKCQLQRHPDCANVKQWKGGPVKIDPLALVQAIERYLVVRGYGRVREDDEDS 1388

  Fly   489 GGGGSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQG------------------------QV 529
            ...||.:....:.:       |.:  :|..|.:....||                        ::
Human  1389 DDDGSDEEIDESLV-------RYY--IPTMYNVLYKVQGLWLKWLLLCFIQAAQFLNSGNVRHRL 1444

  Fly   530 YFY---H-IPTGVSTWHDPRIPRDF-----DTQHLTLDAIGPLPSG--WEQRKTASGRVYFV--- 580
            .||   | :|..::.:   :..|.|     |.:..|.|...||...  |.:..|    :::.
Human  1445 QFYIGEHLLPYNMTVY---QAVRQFSIQAEDERESTDDESNPLGRAGIWTKTHT----IWYKPVR 1502

  Fly   581 --DHNNR------------TTQFTDPRLSGSILQMIRRGTVP----PTSAANAGTPAPPSATPAT 627
              :.:|:            ....|.||.:....::...|..|    |.......|| |.:.|...
Human  1503 EDEESNKDCVGGKRGRAQTAPTKTSPRNAKKHDELWHDGVCPSVSNPLEVYLIPTP-PENITFED 1566

  Fly   628 PSAAA--------------------AVPPQATPASNATPTTLTTTTN-----PPHRIVPDLPQGL 667
            ||...                    |:..:..|.|....:.||...|     |...:..::|..|
Human  1567 PSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPTSEFINSKLTAKANRQLQDPLVIMTGNIPTWL 1631

  Fly   668 LEGADLLP---------------KYRRDLVGKLRALRTELQT-------------MQPQSGHCRL 704
            .|.....|               .:.||     ||::..|.|             :.|:....:.
Human  1632 TELGKTCPFFFPFDTRQMLFYVTAFDRD-----RAMQRLLDTNPEINQSDSQDSRVAPRLDRKKR 1691

  Fly   705 EVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYS 769
            .|:|.|:.:::..::..:.:.  |..|.::::.|.|...|... |:..|:|:|:.....||:
Human  1692 TVNREELLKQAESVMQDLGSS--RAMLEIQYENEVGTGLGPTL-EFYALVSQELQRADLGLW--- 1750

  Fly   770 RDDHYTLQINPDSG---------------------VNPDHLS----YFHFVGRTLGIAVFHGHCL 809
            |.:..||. ||...                     ..|.|::    .|.|:|:.:..|:.....:
Human  1751 RGEEVTLS-NPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLV 1814

  Fly   810 DGGFTTPFYKQLLNK--PITLGDIEGVDPDLHRSLTWM---------LESNISGIIES-TFSVEN 862
            |.....||||.:|.:  .:|..|:..:||.:.||:..:         ||.:.|...|| .:::|.
Human  1815 DLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALET 1879

  Fly   863 NSFGALVVH--------------ELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKG 913
            .:.....|.              |||.||..||||..|..||::|.:.:....|:.:||.:.:.|
Human  1880 LTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDG 1944

  Fly   914 FCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHC------TNETTQVLWFWQVVESY 972
            |..:.|...|:.|...||:.::.| |..|.  |...|.::.|      |:::..|.:.::::.|:
Human  1945 FESVFPLSHLQYFYPEELDQLLCG-SKADT--WDAKTLMECCRPDHGYTHDSRAVKFLFEILSSF 2006

  Fly   973 SSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLT---ADVPTQNLPKAHTCFNRID 1034
            .:|.:...|||||||.|:|:.|||:|       .|.|..:..|   .:.|...||...||.|.:.
Human  2007 DNEQQRLFLQFVTGSPRLPVGGFRSL-------NPPLTIVRKTFESTENPDDFLPSVMTCVNYLK 2064

  Fly  1035 LPPYETYQLLCDKLTQAVEE 1054
            ||.|.:.:::.:||..|..|
Human  2065 LPDYSSIEIMREKLLIAARE 2084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	27/133 (20%)
		WW	169..198	CDD:278809	6/28 (21%)
		WW	514..546	CDD:197736	8/59 (14%)
		WW	562..594	CDD:197736	7/50 (14%)
		HECTc	702..1058	CDD:238033	106/413 (26%)
		HECTc	726..1058	CDD:214523	103/389 (26%)
TRIP12	XP_024308991.1	SR-25	99..>233	CDD:313680
		Arm_3	489..>714	CDD:330530
		WWE	808..874	CDD:308464	2/4 (50%)
		HECTc	1690..2090	CDD:238033	106/412 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810