DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and MAGI1

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001028229.1	Gene:	MAGI1 / 9223	HGNCID:	946	Length:	1462	Species:	Homo sapiens

Alignment Length:	390	Identity:	80/390 - (20%)
Similarity:	122/390 - (31%)	Gaps:	132/390 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 QNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTSPSTTTSPPRHSQSP---------- 410
            ::::|...|.||           |........:::......|.||.| ||..:.|
Human   113 RHFLNQRFQKGS-----------PDHELQQTIRDNLYRHAVPCTTRS-PREGEVPGVDYNFLTVK 165

  Fly   411 ------------------------PTPNISPPAS--VTPSANGNVHSPNANSTPAGSGGGSRSYT 449
                                    |.|...|.:.  :|..|..::.|.:..|||.    .::||.
Human   166 EFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPK----RTKSYN 226

  Fly   450 AATPGQRSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQA--ARPF 512
                ..::......:..||......:|..|.:.|..       ........|:...|.:  |.|.
Human   227 ----DMQNAGIVHAENEEEDDVPEMNSSFTADSGEQ-------EEHTLQETALPPVNSSIIAAPI 280

  Fly   513 LD-------------------LPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRI------P----R 548
            .|                   ||..:||..|:.|:|||....|..::|.|||.      |    .
Human   281 TDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECE 345

  Fly   549 DFDTQHL-TLDAIGPLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRR-------- 604
            |.:..|. .||:...||:|||:.:.....:|:|||.||.||:.:|.|.....:.:.:
Human   346 DDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQ 410

  Fly   605 --------------------GTVPPTSAANAGTPAPPSATPATPSAAAAVPPQATPASNATPTTL 649
                                ..|||..         |:..|:.|..|..||.|..|.....|:.|
Human   411 QQQQQQQQQQQTEEWTEDHSALVPPVI---------PNHPPSNPEPAREVPLQGKPFFTRNPSEL 466

Fly 650 649
Human 467 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	14/50 (28%)
		WW	562..594	CDD:197736	14/31 (45%)
		HECTc	702..1058	CDD:238033
		HECTc	726..1058	CDD:214523
MAGI1	NP_001028229.1	PDZ_signaling	15..100	CDD:238492
		GuKc	122..293	CDD:214504	31/197 (16%)
		WW	303..332	CDD:238122	11/28 (39%)
		WW	361..390	CDD:278809	13/28 (46%)
		PDZ	469..555	CDD:214570
		PDZ	640..723	CDD:214570
		MAGI_u5	722..805	CDD:293271
		PDZ_signaling	819..894	CDD:238492
		PDZ_signaling	968..1062	CDD:238492
		PDZ	1123..1205	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900