DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and HERC3

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_055421.1	Gene:	HERC3 / 8916	HGNCID:	4876	Length:	1050	Species:	Homo sapiens

Alignment Length:	409	Identity:	125/409 - (30%)
Similarity:	207/409 - (50%)	Gaps:	45/409 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   680 DLVGKLRALRT--ELQ-----------------TMQP---QSGHCRLEVSRNEIFEESYRLIMKM 722
            |...|.:.|:|  |||                 |::|   :|....|.|.||.:..::.|.:...
Human   658 DAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELSIH 722

  Fly   723 RAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPD 787
            ...|::|.|.|.|.|||.:|.|||.:|:..||.:|:|||.||:|.|.:|.: .|..:....|  :
Human   723 SDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSN-LLWFSDTCFV--E 784

  Fly   788 HLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISG 852
            | ::||.:|.|.|:|:::...:|..|....||:|||....|.|::.:.|...|||..:|:.....
Human   785 H-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGED 848

  Fly   853 IIES---TFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGF 914
            :.|:   .|::...|:|.:...:|.|||.::.|.::|::|:|..||||.|...:.:.:.|...||
Human   849 VEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGF 913

  Fly   915 CELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLK---HCTNETTQVLWFWQVVESYSSEM 976
            .::....:|..|...||..::.|.|:.:..:.......|   ..|:.|.::  ||:....:..|.
Human   914 LKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKL--FWETFHEFPLEK 976

  Fly   977 RARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETY 1041
            :.:.|.|:|||.|:|:.|..:||          ..|..||. ..:.||.||||:|.:|||.|.:.
Human   977 KKKFLLFLTGSDRIPIYGMASLQ----------IVIQSTAS-GEEYLPVAHTCYNLLDLPKYSSK 1030

  Fly  1042 QLLCDKLTQAVEETCGFAV 1060
            ::|..:||||::...||::
Human  1031 EILSARLTQALDNYEGFSL 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033	113/361 (31%)
		HECTc	726..1058	CDD:214523	108/337 (32%)
HERC3	NP_055421.1	RCC1 1	1..51
		ATS1	2..331	CDD:227511
		RCC1 2	52..101
		RCC1 3	102..154
		RCC1 4	156..207
		RCC1 5	208..259
		RCC1 6	261..311
		RCC1	313..377	CDD:366085
		RCC1 7	313..366
		HECTc	702..1048	CDD:238033	114/362 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810