Protein Alignment Smurf and RSP5

DIOPT Version :10

• Sequence 1: NP_523779.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_011051.3
• Gene: RSP5 / 856862
• SGDID: S000000927
• Length: 809
• Species: Saccharomyces cerevisiae
• Alignment Length: 1076
• Identity: 352/1076 - (32%)
• Similarity: 490/1076 - (45%)
• Gaps: 300/1076 - (27%)

  Fly    15 VRITILCARNLARKDLFRLPDPFAKVQVDGTGQVYSTEISKSSLDPKWNAHYDLFLGIGD--AIT 77
            :.:.::.|.:|.::|:||.|||||.:.:||. |..||..:|.:|:|.||..:. |..|.:  .:|
Yeast     5 ISVKLVAAESLYKRDVFRSPDPFAVLTIDGY-QTKSTSAAKKTLNPYWNETFK-FDDINENSILT 67

  Fly    78 ITVWNQRKI-HKGSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSPDDDELVRGQIIISLLSKDGP 141
            |.|::|:|. .|..||||.|.:...::            ||.|..|                ...
Yeast    68 IQVFDQKKFKKKDQGFLGVVNVRVGDV------------LGHLDED----------------TAT 104

  Fly   142 SSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTD----NGRVYYVNHATKSTQWDRPRQPG 202
            |||.             |.|:..:.|.      ::..|    :||:..|.....|:
Yeast   105 SSGR-------------PREETITRDL------KKSNDGMAVSGRLIVVLSKLPSS--------- 141

  Fly   203 VVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHSTEILS 267
               |.|:.:|          ||...:.:..|.|||.|    |||       :.|..|.|||
Yeast   142 ---SPHSQAP----------SGHTASSSTNTSSTTRT----NGH-------STSSTRNHST---- 178

  Fly   268 SVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSST--TSASVRLHSN-- 328
                     :.|...|....:.|..|.:::|         ||...|...||  ||::.|.:|:
Yeast   179 ---------SHPSRGTAQAVESTLQSGTTAA---------TNTATTSHRSTNSTSSATRQYSSFE 225

  Fly   329 DNHVKTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAAT 393
            |.:.:.|        |.....|...|:..||:.|.:
Yeast   226 DQYGRLP--------PGWERRTDNFGRTYYVDHNTR----------------------------- 253

  Fly   394 TTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQRSQ 458
                :||...|...|             |.:..||  ..|||
Yeast   254 ----TTTWKRPTLDQ-------------TEAERGN--QLNAN----------------------- 276

  Fly   459 RRSSRQQGEESSTRRRSSRG-TRNGGTSGGGG-----GGGSG----QRYASAAIAAANQAARPFL 513
                      :...||..|| |..||:|....     ||||.    ...|:||.||.........
Yeast   277 ----------TELERRQHRGRTLPGGSSDNSSVTVQVGGGSNIPPVNGAAAAAFAATGGTTSGLG 331

  Fly   514 DLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRI--------PRDFDTQHLTLDAIGPLPSGWEQR 570
            :||.|:|.|.|.:|:.||....|..:||.|||.        |.:...|...:..:||||||||.|
Yeast   332 ELPSGWEQRFTPEGRAYFVDHNTRTTTWVDPRRQQYIRTYGPTNTTIQQQPVSQLGPLPSGWEMR 396

  Fly   571 KTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAAAAVP 635
            .|.:.||||||||.:||.:.||||..|:.|.:
Yeast   397 LTNTARVYFVDHNTKTTTWDDPRLPSSLDQNV--------------------------------- 428

  Fly   636 PQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTMQPQSG 700
                                                   |:|:||...|:...|:: ..::...|
Yeast   429 ---------------------------------------PQYKRDFRRKVIYFRSQ-PALRILPG 453

  Fly   701 HCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGL 765
            .|.::|.|..|||::|:.||:...:|::||||:||.||||||||||:||:..|||.||.||.|.|
Yeast   454 QCHIKVRRKNIFEDAYQEIMRQTPEDLKKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNPFYCL 518

  Fly   766 FQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGD 830
            |:||..|:||:||||:||:||:||:||.|:||.:|:.|||...||..|....||.:|.|.:.|.|
Yeast   519 FEYSAYDNYTIQINPNSGINPEHLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLRKKVVLQD 583

  Fly   831 IEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYV 895
            :||||.:::.||.||||::|.|:::.|||.::..||.:|..:|||.|.:|.||:.||:|||:||.
Yeast   584 MEGVDAEVYNSLNWMLENSIDGVLDLTFSADDERFGEVVTVDLKPDGRNIEVTDGNKKEYVELYT 648

  Fly   896 NYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNETT 960
            .:|.:..:::||.|...||.||||..|:..||||||||:||||:.||:.||:.:|..:.......
Yeast   649 QWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEIDIEDWKKHTDYRGYQESDE 713

  Fly   961 QVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPK 1025
            .:.|||:.|..:.:|.|||||||.||:||:|:.||:.||||.   |||.|||....:|  |.|||
Yeast   714 VIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQGSD---GPRRFTIEKAGEV--QQLPK 773

  Fly  1026 AHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061
            :||||||:|||.|..|..:..|||.|||||.||..|
Yeast   774 SHTCFNRVDLPQYVDYDSMKQKLTLAVEETIGFGQE 809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_523779.1	C2_Smurf-like	14..135	CDD:176028	37/122 (30%)
		PRP40	155..>283	CDD:227435	27/131 (21%)
		WW	169..198	CDD:459800	5/32 (16%)
		WW	514..546	CDD:197736	14/31 (45%)
		WW	562..594	CDD:197736	21/31 (68%)
		HECTc	702..1058	CDD:238033	184/355 (52%)
RSP5	NP_011051.3	HUL4	3..809	CDD:227354	351/1074 (33%)