DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and UFD4

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_012915.3	Gene:	UFD4 / 853859	SGDID:	S000001493	Length:	1483	Species:	Saccharomyces cerevisiae

Alignment Length:	407	Identity:	105/407 - (25%)
Similarity:	184/407 - (45%)	Gaps:	82/407 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   703 RLEVSRNEIFEESYRLIMKM-RAKDMRKRLMVKFKGEEG------LDYGGVAREWLHLLSREMLN 760
            :|.:||..||....:::.|. .:.|:   |.::::.|.|      |::..|..::   .:|:.||
Yeast  1102 KLRISRKTIFATGLKILSKYGSSPDV---LEIEYQEEAGTGLGPTLEFYSVVSKY---FARKSLN 1160

  Fly   761 P-QYGLFQY-------SRDDHYTL-----QINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGG 812
            . :...:.|       :.||:.|.     .:||.|. |...:..|.::|..:..::.....||..
Yeast  1161 MWRCNSYSYRSEMDVDTTDDYITTLLFPEPLNPFSN-NEKVIELFGYLGTFVARSLLDNRILDFR 1224

  Fly   813 FTTPFYKQLLNKPIT-------------LGDIEGVDPDLHRSLTWML---ESNISGIIES---TF 858
            |:..|: :||::..|             |..||.|||.|.:||.:::   :.|::  :||   ||
Yeast  1225 FSKVFF-ELLHRMSTPNVTTVPSDVETCLLMIELVDPLLAKSLKYIVANKDDNMT--LESLSLTF 1286

  Fly   859 SVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLL 923
            :|..|.     ..||.|||.:..:...|..||:...::....:|||:|..|..:||.::.....:
Yeast  1287 TVPGND-----DIELIPGGCNKSLNSSNVEEYIHGVIDQILGKGIEKQLKAFIEGFSKVFSYERM 1346

  Fly   924 RPFDERELELVIGGISSIDVNDWR-----NNTRLKH-CTNETTQVLWFWQVVESYSSEMRARLLQ 982
            ......||..:.|.:.    .||.     .|...:| .|.:::.:..|..::.::....|...||
Yeast  1347 LILFPDELVDIFGRVE----EDWSMATLYTNLNAEHGYTMDSSIIHDFISIISAFGKHERRLFLQ 1407

  Fly   983 FVTGSSRVPLQGFRALQGSTGAVGPRLFTI---H----LTADVPTQNLPKAHTCFNRIDLPPYET 1040
            |:|||.::|:.||::|       .|: ||:   |    ||||   :.||...||.|.:.||.|.:
Yeast  1408 FLTGSPKLPIGGFKSL-------NPK-FTVVLKHAEDGLTAD---EYLPSVMTCANYLKLPKYTS 1461

  Fly  1041 YQLLCDKLTQAVEETCG 1057
            ..::..:|.||:||..|
Yeast  1462 KDIMRSRLCQAIEEGAG 1478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033	105/407 (26%)
		HECTc	726..1058	CDD:214523	99/383 (26%)
UFD4	NP_012915.3	HUL4	581..1482	CDD:227354	105/407 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900