DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and HUL4

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_012570.3	Gene:	HUL4 / 853494	SGDID:	S000003797	Length:	892	Species:	Saccharomyces cerevisiae

Alignment Length:	380	Identity:	113/380 - (29%)
Similarity:	188/380 - (49%)	Gaps:	36/380 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   703 RLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQ 767
            :::|.|:.|..:|.|.| |....|:.|.|.::|..|.|:|.||:.:||..||::.:.||..|||.
Yeast   522 KIKVRRDVISHDSLRCI-KEHQGDLLKSLRIEFVNEPGIDAGGLRKEWFFLLTKSLFNPMNGLFI 585

  Fly   768 YSRDDHYT-LQINP-----DSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPI 826
            |.::...: ..|:|     ..|.| ..|..::..|..:|:|:|:...||..|....||:|.::|:
Yeast   586 YIKESSRSWFAIDPPNFDKSKGKN-SQLELYYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPL 649

  Fly   827 TLGDIEGVDPDLHRSLTWML---ESNISGIIESTFSV----------ENNSFGALVVHELKPGGA 878
            :..|...:.|:..|:|..||   |.|...:...||..          ::.|....|..||...|.
Yeast   650 SFEDYSELFPETSRNLIKMLNYTEDNFEDVFSLTFETTYRNNNWILNDSKSSKEYVTVELCENGR 714

  Fly   879 SIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPS-HLLRPFDERELELVIGG---IS 939
            ::|:|:.||.|:|..:|.:...:.||.|:.....||..:... :.::.|:..|||.::.|   .:
Yeast   715 NVPITQSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLVCGDEEQT 779

  Fly   940 SIDVNDWRNNTR-LKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTG 1003
            ..|....|:.|: :...::::..|.|||:::||:...::.:||||||.|.|:|..|...:.
Yeast   780 KFDFKSLRSVTKYVGGFSDDSRAVCWFWEIIESWDYPLQKKLLQFVTASDRIPATGISTIP---- 840

  Fly  1004 AVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGF 1058
                  |.|.|.....:.:||.||||||.|.|..|.:.:.|..||..|:.|:.|:
Yeast   841 ------FKISLLGSHDSDDLPLAHTCFNEICLWNYSSKKKLELKLLWAINESEGY 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033	112/378 (30%)
		HECTc	726..1058	CDD:214523	105/355 (30%)
HUL4	NP_012570.3	HUL4	1..892	CDD:227354	113/380 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810