DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and GAS7

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_958839.1	Gene:	GAS7 / 8522	HGNCID:	4169	Length:	476	Species:	Homo sapiens

Alignment Length:	217	Identity:	55/217 - (25%)
Similarity:	82/217 - (37%)	Gaps:	55/217 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 GQIIISLLSKDG---------------PSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRT 178
            |::|..|...||               |:|  .:.::...|.|..|..::|....||.||:...:
Human    26 GELITLLQVPDGGWWEGEKEDGLRGWFPAS--YVQLLEKPGMVPPPPGEESQTVILPPGWQSYLS 88

  Fly   179 DNGRVYYVNHATKSTQWDRP-RQPGVVGS--SHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTN 240
            ..||.||||..|..|.|:|| ..||:..|  ||.:|.....|.::.:.    .||.|..:...:.
Human    89 PQGRRYYVNTTTNETTWERPSSSPGIPASPGSHRSSLPPTVNGYHASG----TPAHPPETAHMSV 149

  Fly   241 LMNNGHRSRDLSVTASDERRHSTEILSSVGKENT----------SPTTPVSATTTP--------- 286
            ..:.|. |::|. ::|..::.|        ||||          ..|.|......|
Human   150 RKSTGD-SQNLG-SSSPSKKQS--------KENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYF 204

  Fly   287 --GKKTSSSNSSSAGGRTLEQR 306
              .||....|.:.||...|.|:
Human   205 WADKKDPQGNGTVAGFELLLQK 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	2/5 (40%)
		WW	169..198	CDD:278809	13/28 (46%)
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033
		HECTc	726..1058	CDD:214523
GAS7	NP_958839.1	SH3_GAS7	5..57	CDD:212763	7/32 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..171		20/84 (24%)
		WW_FCH_linker	109..201	CDD:374680	22/105 (21%)
		F-BAR_GAS7	214..446	CDD:153333	5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900