DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and TOM1

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_010745.3	Gene:	TOM1 / 852068	SGDID:	S000002865	Length:	3268	Species:	Saccharomyces cerevisiae

Alignment Length:	352	Identity:	156/352 - (44%)
Similarity:	219/352 - (62%)	Gaps:	5/352 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   704 LEVSRNEIFEESYR-LIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQ 767
            :.|.|.::|.:||| |..|...:....:|.:.||||.|:|.|||.|||..:|||:|.||.|.||.
Yeast  2913 ITVRREQVFLDSYRALFFKTNDEIKNSKLEITFKGESGVDAGGVTREWYQVLSRQMFNPDYALFL 2977

  Fly   768 YSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIE 832
            ....|..|...|..||:||:|||:|.|:|..:|.|:.....||..|:...||.:|.:|::|.|:|
Yeast  2978 PVPSDKTTFHPNRTSGINPEHLSFFKFIGMIIGKAIRDQCFLDCHFSREVYKNILGRPVSLKDME 3042

  Fly   833 GVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNY 897
            .:|||.::||.|:||::|:.|||.|||||.:.:|...|..|..||..|.|||.||::|||..|.|
Yeast  3043 SLDPDYYKSLVWILENDITDIIEETFSVETDDYGEHKVINLIEGGKDIIVTEANKQDYVKKVVEY 3107

  Fly   898 RFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQV 962
            :....:::|......||..||...|:..|||:||||:|.|:..|||:||:|||...:.|....:|
Yeast  3108 KLQTSVKEQMDNFLVGFYALISKDLITIFDEQELELLISGLPDIDVDDWKNNTTYVNYTATCKEV 3172

  Fly   963 LWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAH 1027
            .:||:.|.|:.:|.||:|||||||:|:|||.||:.|.|..|..   .|:||.... .::.||.:|
Yeast  3173 SYFWRAVRSFDAEERAKLLQFVTGTSKVPLNGFKELSGVNGVC---KFSIHRDFG-SSERLPSSH 3233

  Fly  1028 TCFNRIDLPPYETYQLLCDKLTQAVEE 1054
            ||||:::|||||:|:.|...|..|:.|
Yeast  3234 TCFNQLNLPPYESYETLRGSLLLAINE 3260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033	156/352 (44%)
		HECTc	726..1058	CDD:214523	148/329 (45%)
TOM1	NP_010745.3	DUF908	92..387	CDD:399185
		DUF913	448..>683	CDD:399192
		MSCRAMM_ClfB	<1879..2061	CDD:411414
		DUF4414	2328..2357	CDD:405126
		HUL4	2385..3268	CDD:227354	156/352 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810