DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Smurf and Nedd4l

DIOPT Version :9

Sequence 1:NP_001261061.1 Gene:Smurf / 36999 FlyBaseID:FBgn0029006 Length:1061 Species:Drosophila melanogaster
Sequence 2:XP_036017204.1 Gene:Nedd4l / 83814 MGIID:1933754 Length:1261 Species:Mus musculus


Alignment Length:1093 Identity:338/1093 - (30%)
Similarity:474/1093 - (43%) Gaps:301/1093 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 NQRKIHKGSG-----------FLGCVRIPAFNI--------------------QSLKG--AGFQR 113
            ||.:.||..|           |||.|.:|..::                    :|.|.  .||.|
Mouse   350 NQEETHKSPGHPGAGAPTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLR 414

  Fly   114 LDLGKL----------SPDDDELVRGQIIISLLSKDGPSSGNPLAIVGPSGDVRGPSEDDSSEDS 168
            |.:..:          |...|::..|..::.                  |.|.....:::.....
Mouse   415 LKMAYMPKNGGQDEENSEQRDDMEHGWEVVD------------------SNDSASQHQEELPPPP 461

  Fly   169 LPEGWEERRTDNGRVYYVNHATKSTQWDRPRQPGVVGSSHATSPQQRHNTHNGNSGDRQAPAGPT 233
            ||.||||:..:.||.|||||..:||||.||       |....|.:..:|....|   ::|.....
Mouse   462 LPPGWEEKVDNLGRTYYVNHNNRSTQWHRP-------SLMDVSSESDNNIRQIN---QEAAHRRF 516

  Fly   234 RSTTCTNLMNNGHRSRDLSVTASDERRHSTEILSSVGKENTS---------PTTPVSATTTPGKK 289
            ||        ..|.|.||...||:......|...::.:|...         |..|.|    |..:
Mouse   517 RS--------RRHISEDLEPEASEGGGEGPEPWETISEEMNMAGDSLSLALPPPPAS----PVSR 569

  Fly   290 TSSSNSSSAGGRTLEQRPTNE--------PATPTSSTTSASVRLHSNDNHVKTPKHQTNGHAPPE 346
            ||....|....|.|:..|.:.        ...|:|...|.||          |.......|.||.
Mouse   570 TSPQELSEEVSRRLQITPDSNGEQFSSLIQREPSSRLRSCSV----------TDTVAEQAHLPPP 624

  Fly   347 STPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSA--------SNGWTQ-EDAATTT-----SP 397
            ||||.          .|::.:.:|   |:.:.|..|        .:||.: :||...|     :.
Mouse   625 STPTR----------RARSSTVTG---GEESTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNN 676

  Fly   398 STTTSPPRHSQSPPTPNISPPASVTPSANGNVH-------SPNANSTPAGSGGGSRSYTAATPGQ 455
            .|||      .:.|...::...:...:.|.|.|       .|.:.|:|        :.|.:.|  
Mouse   677 RTTT------WTRPIMQLAEDGASGSATNSNNHLVEPQIRRPRSLSSP--------TVTLSAP-- 725

  Fly   456 RSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYE 520
                    .:|.:.|..||:.:.|.:...|.......|.:        ..::..:.|  ||||:|
Mouse   726 --------LEGAKDSPIRRAVKDTLSNPQSPQPSPYNSPK--------PQHKVTQSF--LPPGWE 772

  Fly   521 MRTTQQGQVYFYHIPTGVSTWHDPRI-------------PRDFDTQHLTLDAIGPLPSGWEQRKT 572
            ||....|:.:|....|..:||.|||:             |.|          :||||.|||:|..
Mouse   773 MRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPND----------LGPLPPGWEERIH 827

  Fly   573 ASGRVYFVDH------------------NNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPA 619
            ..||.:::||                  :::.||:.||||..                       
Mouse   828 LDGRTFYIDHSSQVLCGENDTRESVPLYDSKITQWEDPRLQN----------------------- 869

  Fly   620 PPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGK 684
            |....||.|                                                |.|:...|
Mouse   870 PAITGPAVP------------------------------------------------YSREFKQK 886

  Fly   685 LRALRTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRK-RLMVKFKGEEGLDYGGVAR 748
            ....|.:|:..........:::.||.|||||||.||.::..|:.| ||.::|:.|:|||||||||
Mouse   887 YDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAR 951

  Fly   749 EWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGV-NPDHLSYFHFVGRTLGIAVFHGHCLDGG 812
            ||..|||:||.||.||||:||..|:|||||||:||: |.||||||.|:||..|:|||||..|||.
Mouse   952 EWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGF 1016

  Fly   813 FTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHELKPGG 877
            |..||||.:|.|.|||.|:|.||.:.:.||.|:||::.:. ::..|.::..:||.....:|||.|
Mouse  1017 FIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNG 1080

  Fly   878 ASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSID 942
            :.|.||.||||||:.|.:.:||:..:::|..|..:||.||:|..|::.|||.||||::.|:..:|
Mouse  1081 SEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 1145

  Fly   943 VNDWRNNTRLK--HCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAV 1005
            |||||.::..|  :|.|... :.|||:.|....:|.|.||||||||:||||:.||..|.||.   
Mouse  1146 VNDWRQHSIYKNGYCPNHPV-IQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSN--- 1206

  Fly  1006 GPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGF 1058
            ||:||||.....  .:.||:|||||||:|||||||::.|.:||..|||...||
Mouse  1207 GPQLFTIEQWGS--PEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 1257

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmurfNP_001261061.1 C2_Smurf-like 14..135 CDD:176028 19/95 (20%)
WW 169..198 CDD:278809 17/28 (61%)
WW 514..546 CDD:197736 14/31 (45%)
WW 562..594 CDD:197736 15/49 (31%)
HECTc 702..1058 CDD:238033 184/359 (51%)
HECTc 726..1058 CDD:214523 173/335 (52%)
Nedd4lXP_036017204.1 PHA03378 <107..318 CDD:223065
C2 <367..420 CDD:417471 11/52 (21%)
WW 465..491 CDD:395320 15/25 (60%)
WW 655..684 CDD:395320 8/34 (24%)
WW 768..798 CDD:238122 13/29 (45%)
WW 817..867 CDD:197736 15/49 (31%)
HECTc 928..1257 CDD:214523 173/335 (52%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100256
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2273
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.740

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