Protein Alignment Smurf and WWC2

DIOPT Version :9

• Sequence 1: NP_001261061.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_011530571.1
• Gene: WWC2 / 80014
• HGNCID: 24148
• Length: 1216
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 128/560 - (22%)
• Similarity: 187/560 - (33%)
• Gaps: 158/560 - (28%)

  Fly   492 GSGQRYASAAIAAANQAARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLT 556
            ||||                 |.||.|:|......|:|::....|..::|.|   |||..|:.|:
Human     6 GSGQ-----------------LPLPRGWEEARDYDGKVFYIDHNTRRTSWID---PRDRLTKPLS 50

  Fly   557 L-DAIG-PLPSGWEQRKTASGRVYFVDHNNRTTQFTDPRLS--GSILQMIRRGTVPPTSAANAGT 617
            . |.:| .||.|||........||::||.|:|||..|||..  |...:|::    ...|.|....
Human    51 FADCVGDELPWGWEAGFDPQIGVYYIDHINKTTQIEDPRKQWRGEQEKMLK----DYLSVAQDAL 111

  Fly   618 PAPPSATPATPSAAAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLV 682
            ..............|....:....::|.....::.|:            |..|:....||..|:
Human   112 RTQKELYHVKEQRLALALDEYVRLNDAYKEKSSSHTS------------LFSGSSSSTKYDPDI- 163

  Fly   683 GKLRALRTELQTMQPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVA 747
                 |:.|:.|       .||.|.:           :|.....|::.|:.|   |:|.
Human   164 -----LKAEIST-------TRLRVKK-----------LKRELSQMKQELLYK---EQGF------ 196

  Fly   748 REWLHLLSREMLNPQYGLFQYSRDDHYTLQINP-----DSGVNPDH---------LSYFHF---V 795
             |.|..:.::|...|.| ::.|.......::..     .||.....         ...||.   :
Human   197 -ETLQQIDKKMSGGQSG-YELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNI 259

  Fly   796 GRT---LGIAVFHGH-C-----LDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNIS 851
            ||:   |..:..:.| |     ||.|..|..          .||| ||     ||     .||::
Human   260 GRSEPDLRCSPVNSHLCLSRQTLDAGSQTSI----------SGDI-GV-----RS-----RSNLA 303

  Fly   852 GIIESTFSVE--NNSFGALVVH------ELKPGGASIPVTE----ENKREYVKLYVNYRFMRGIE 904
            ..:..:...|  ..|...|.:.      |..||...|...:    ..|.|.:|           |
Human   304 EKVRLSLQYEEAKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELLK-----------E 357

  Fly   905 QQFLALQKGF-CELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHC---TNETTQVLWF 965
            .||:..||.. .||......|...|.||..|.|..|.......|...|.|..   ..|||::..:
Human   358 LQFVTPQKRTQDELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLTTY 422

  Fly   966 WQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAV 1005
               :.|....:.|..|...:|||      ..:|..|.|::
Human   423 ---LHSQLKSLSASTLSMSSGSS------LGSLASSRGSL 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736	9/31 (29%)
		WW	562..594	CDD:197736	15/31 (48%)
		HECTc	702..1058	CDD:238033	76/346 (22%)
		HECTc	726..1058	CDD:214523	72/322 (22%)
WWC2	XP_011530571.1	WW	12..41	CDD:278809	9/31 (29%)
		WW	59..88	CDD:278809	13/28 (46%)
		DUF342	<283..385	CDD:302792	31/133 (23%)
		YlqD	351..>428	CDD:287979	24/90 (27%)
		C2_Kibra	700..823	CDD:176062
		vWFA	<1058..>1153	CDD:294047
		Phage_Nu1	<1117..1192	CDD:294991

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900