DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and MAGIX

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_079135.3	Gene:	MAGIX / 79917	HGNCID:	30006	Length:	334	Species:	Homo sapiens

Alignment Length:	298	Identity:	67/298 - (22%)
Similarity:	94/298 - (31%)	Gaps:	108/298 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 FNIQSLKG-AGFQRLDLG---KLSPDDDELVRGQIIISLLSKDGPSSG-NPLAIVGPSGD----V 156
            |:::.::| ||| .|.||   .::.|....|||      |.||||:.. ..|.:    ||    :
Human   124 FSVELVRGYAGF-GLTLGGGRDVAGDTPLAVRG------LLKDGPAQRCGRLEV----GDLVLHI 177

  Fly   157 RGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDRPR-----QPGVVGSSHATSPQQRH 216
            .|.|....:.   .:..|..|....:::.|......|...:||     :.|||.|....||.
Human   178 NGESTQGLTH---AQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPD--- 236

  Fly   217 NTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHSTEILSSVGKENTSPTTPVS 281
                        |.||                   .||.|  |..||.::..          |.|
Human   237 ------------PGGP-------------------EVTGS--RSSSTSLVQH----------PPS 258

  Fly   282 ATTTPGKKTSSSNSSSAGGRTLEQRPTNEPAT--PTSSTTSASVRLHSNDNHVKTPKHQTNGHAP 344
            .||.  |||..|           ..|:.|.|.  ||.|..         :...:.|..|..|...
Human   259 RTTL--KKTRGS-----------PEPSPEAAADGPTVSPP---------ERRAEDPNDQIPGSPG 301

  Fly   345 PESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSA 382
            |...|:.          ...:.:....|:.|.||..:|
Human   302 PWLVPSE----------ERLSRALGVRGAAQLAQEMAA 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	12/37 (32%)
		WW	169..198	CDD:278809	4/28 (14%)
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033
		HECTc	726..1058	CDD:214523
MAGIX	NP_079135.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		PDZ_signaling	124..206	CDD:238492	25/95 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..306		36/164 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900