DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and herc5.2

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_005160175.1	Gene:	herc5.2 / 794323	ZFINID:	ZDB-GENE-090311-16	Length:	987	Species:	Danio rerio

Alignment Length:	367	Identity:	99/367 - (26%)
Similarity:	174/367 - (47%)	Gaps:	39/367 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   704 LEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQY 768
            |.::|..:..::.: .::...........|.|.||:|:|..|::.|:..|:|:..|
Zfish   651 LHINRESLLMDTLK-YLRQNTHSFSHLSRVAFIGEDGIDMRGLSAEFFSLISKSFL--------- 705

  Fly   769 SRDDHYTLQINPDSGV--NPDHL---SYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITL 828
             :.|...|:::|.|.|  ||.|.   ..|:::|...|:|:::.|.::..|....:|:||.:..:|
Zfish   706 -KWDKKILEVHPSSLVWFNPHHTRGNKNFYYLGVICGMALYNRHHINIDFPLALFKKLLQQKPSL 769

  Fly   829 GDIEGVDPDLHRSLTWML--ESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREYV 891
            .|:|.:.|...|||..:|  :..:..::...|:|:.        |||.|.|:.|.|.:.|:::||
Zfish   770 DDLEELSPVEARSLKNLLKEDEEVVDLLFLDFTVKG--------HELVPNGSQIQVNKVNRQKYV 826

  Fly   892 KLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCT 956
            .|||::.|.:.::.||....:||.:..|......|...||:.::.|....:..:::.:...:.|:
Zfish   827 DLYVDFVFNKSVKTQFEQFTRGFSKGCPLDAWTMFHPEELQELLHGSPQYNWKEFQQSASYEGCS 891

  Fly   957 NETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGF--RALQGSTGAVGPRLFTIHLTADVP 1019
            .....:..||.|....|.|.:.:.|.|:.|:.|||..||  |.::.||           .....|
Zfish   892 ASDELIKNFWTVFFELSEEHKKKFLMFLYGTERVPAGGFSKRRIKIST-----------RDCPDP 945

  Fly  1020 TQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061
            ..:||||.|||.|:.||.|.....|.:|||.|:.....|.:|
Zfish   946 DDHLPKAQTCFGRLVLPKYTDINTLRNKLTHAINVCEVFGLE 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033	97/362 (27%)
		HECTc	726..1058	CDD:214523	95/340 (28%)
herc5.2	XP_005160175.1	RCC1_2	120..149	CDD:290274
		RCC1	136..186	CDD:278826
		RCC1	189..238	CDD:278826
		RCC1	242..290	CDD:278826
		RCC1	296..347	CDD:278826
		HECTc	649..985	CDD:294058	97/363 (27%)
		HECTc	678..984	CDD:214523	95/334 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810