DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and ube3a

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001007319.1	Gene:	ube3a / 792398	ZFINID:	ZDB-GENE-041114-190	Length:	857	Species:	Danio rerio

Alignment Length:	958	Identity:	219/958 - (22%)
Similarity:	360/958 - (37%)	Gaps:	212/958 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 RRTDNGRV------YYVNHATKSTQWDRPRQPGVVGSSHATSPQQRHN---THNGNSGDRQAPAG 231
            :|.||...      .|.|:|....  ..|.:.|...:....|.:..||   ..||....:..|
Zfish    38 QRMDNNAAAIKALELYKNNAKLCD--PHPSKKGASSAFPENSAKGAHNFSACSNGKMNHKDLP-- 98

  Fly   232 PTRSTTCTNLMNNGHRSRDLSVTASDERRHSTEILSSVGK-ENTSPTTPVSATTTPGKKTSSSNS 295
            |||..           .|||:....|:   ..||||...: |:.||...|.     |:..||:.|
Zfish    99 PTRED-----------FRDLNFLTEDK---VYEILSICSETEDYSPLIRVI-----GRVFSSAES 144

  Fly   296 SSAGGRTLEQ---------------RPTNEPATPTSSTTSASVRLHSNDNHVKTPKHQTNGHAPP 345
            .....|..:|               :..:|..|.:.|:|:..|.                    |
Zfish   145 LVQSFRKAKQHTKEELKSLQAKDEDKDEDEKETASGSSTAMEVE--------------------P 189

  Fly   346 ESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQP---------------QSASNGWTQE---DAA 392
            |::.:|            .:||:.|..:.|...|               :..||...:.   :|.
Zfish   190 EASASS------------GDGSSHGENNVQKLGPVEVSVDIDAVRRVYDRLLSNEKIEAAFLNAL 242

  Fly   393 TTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPN--ANSTPAGSGGGSRSYTAATPGQ 455
            ...||:.......|:.....||.. ...:....|.|:|||.  ..:.|......|:   ...|..
Zfish   243 VYLSPNVECDLTYHNVYAADPNYL-NVFIIVMENSNLHSPEYLEIALPQFCKAMSK---LPLPAL 303

  Fly   456 RSQRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYE 520
            ....|...|.|.:...|...                 :.|:..:..:.:...::...::...|..
Zfish   304 AKLARLWSQYGVDQIRRLVE-----------------TFQQLITYTVISNEFSSDNLVNEDDGVV 351

  Fly   521 MRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLDAIGPLPSG---------WEQRKTASGR 576
            ..|.....||:.::..|           |.||.|...|...|:|..         .|:|:...|
Zfish   352 AATKCLKIVYYANVLGG-----------DLDTDHNEEDDDEPIPESSELTLQELLGEERRNKKG- 404

  Fly   577 VYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSAAAAVPP---QA 638
                           ||:.....:|              |..|.....|..|.......|   ..
Zfish   405 ---------------PRVDPLETEM--------------GIRASDCRKPLIPFEEFINEPLNEVL 440

  Fly   639 TPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLR--ALRTELQTMQPQSGH 701
            ....:.|...:.|.:.......|.:...:.:...|....|..:..:.|  ||.:.:|..| .:.:
Zfish   441 EMDKDYTFFKVETESKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITALYSLVQGQQ-LNPY 504

  Fly   702 CRLEVSRNEIFEES---YRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQY 763
            .||:|.|:.|.:::   ..:|......|::|:|.|:|:||:|:|.|||::|:..|:..|:.||..
Zfish   505 LRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDI 569

  Fly   764 GLFQYSRDDHYT--LQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPI 826
            |:|.|   |..|  ...||.|..|.   ..|..:|..||:|:::...||..|....|::|:.|..
Zfish   570 GMFTY---DESTKLFWFNPSSFENE---GQFTLIGIVLGLAIYNNCILDVHFPMVIYRKLMGKKG 628

  Fly   827 TLGDIEGVDPDLHRSLTWML--ESNISGIIESTFSV-ENNSFGALVVHELKPGGASIPVTEENKR 888
            |..|:....|.|.:||..::  |.|:...:..||.: :.:.||..::::||..|..||||.||::
Zfish   629 TFRDLADSHPVLFQSLKDLMEYEGNVEEDMMITFQISQTDLFGNPLMYDLKESGDKIPVTNENRK 693

  Fly   889 EYVKLYVNYRFMRGIEQQFLALQKGFCELIPS-----HLLRPFDERELELVIGGISSIDVNDWRN 948
            ::|.||..|...:.:|:||.|.::|| .::.:     :|.||   .|:||:|.|..::|......
Zfish   694 DFVALYAEYMLNKSVEKQFKAFRRGF-HMVTNESPLKYLFRP---EEIELLICGSRNLDFQALEE 754

  Fly   949 NTRLKHCTNETTQVLW-FWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTI 1012
            :|......|:.::::. ||:.|.|:..|.:...|||.||:.|.|:.|...|:......||
Zfish   755 STEYDGGYNKDSRIIRDFWETVHSFEQEKKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGP----- 814

  Fly  1013 HLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAV 1060
                  .:..||.:|||||.:.||.|.|.:.|.::|.:|:....||.:
Zfish   815 ------DSDRLPTSHTCFNVLLLPEYSTVEKLKERLLKAITYAKGFGM 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809	6/27 (22%)
		WW	514..546	CDD:197736	5/31 (16%)
		WW	562..594	CDD:197736	6/40 (15%)
		HECTc	702..1058	CDD:238033	115/369 (31%)
		HECTc	726..1058	CDD:214523	109/342 (32%)
ube3a	NP_001007319.1	AZUL	6..60	CDD:293166	6/21 (29%)
		HECTc	505..855	CDD:238033	116/370 (31%)
		HECTc	532..854	CDD:214523	109/342 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810