Protein Alignment Smurf and Smurf1

DIOPT Version :10

• Sequence 1: NP_523779.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_006504947.1
• Gene: Smurf1 / 75788
• MGIID: 1923038
• Length: 757
• Species: Mus musculus
• Alignment Length: 1081
• Identity: 462/1081 - (42%)
• Similarity: 559/1081 - (51%)
• Gaps: 357/1081 - (33%)

  Fly     8 RRNGTH-KVRITILCARNLARKDLFRLPDPFAKVQVDGTGQVYSTEISKSSLDPKWNAHYDLFLG 71
            ||||:. |:|:|:|||:|||:||.|||||||||:.|||:||.:||:..|::||||||.||||::|
Mouse     7 RRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVG 71

  Fly    72 IGDAITITVWNQRKIHK--GSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSPDDDELVRGQIIIS 134
            ..|:|||:|||.:||||  |:|||||||:.:..|..||..|:|||||.||:|.|.:.|||||::|
Mouse    72 KTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVS 136

  Fly   135 LLSKDGPSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDRPR 199
            |.::|....|      |...|.||..|::                 |.||
Mouse   137 LQTRDRIGGG------GSVVDCRGLLENE-----------------GTVY--------------- 163

  Fly   200 QPGVVGSSHATSPQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHSTE 264
                                        ..:||.|..:|  ||
Mouse   164 ----------------------------EDSGPGRPLSC--LM---------------------- 176

  Fly   265 ILSSVGKENTSPTTPVSATTTPGKKTSSSNSSSAGGRTLEQRPTNEPATPTSSTTSASVRLHSND 329
                   |..:|.|..:.....|.......|.|...|.|.||..|           ..||
Mouse   177 -------EEPAPYTDGTGAAAGGGNCRFVESPSQDQRLLVQRLRN-----------PEVR----- 218

  Fly   330 NHVKTPKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATT 394
            ..::||:::.:||..||
Mouse   219 GPLQTPQNRPHGHQSPE------------------------------------------------ 235

  Fly   395 TSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGGSRSYTAATPGQRSQR 459
                                                                             
Mouse   236 ----------------------------------------------------------------- 235

  Fly   460 RSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQRYASAAIAAANQAARPFLDLPPGYEMRTT 524
                                                                   ||.|||.|||
Mouse   236 -------------------------------------------------------LPEGYEQRTT 245

  Fly   525 QQGQVYFYHIPTGVSTWHDPRIPRDF------------------------DTQHLTLDAIGPLPS 565
            .||||||.|..||||||||||||...                        |...:..|.:||||.
Mouse   246 VQGQVYFLHTQTGVSTWHDPRIPSPLGTIPGGDEAFLYEFLLQGHTSEPRDLNSVNCDELGPLPP 310

  Fly   566 GWEQRKTASGRVYFVDHNNRTTQFTDPRLSGSILQMIRRGTVPPTSAANAGTPAPPSATPATPSA 630
            |||.|.|.|||:|||||||||||||||||...:           ........|:.|...|:..|
Mouse   311 GWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIM-----------NHQCQLKEPSQPLQLPSEGS- 363

  Fly   631 AAAVPPQATPASNATPTTLTTTTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTELQTM 695
               |..:..||.                                 :|.||||.||:.||.||...
Mouse   364 ---VEDEELPAQ---------------------------------RYERDLVQKLKVLRHELSLQ 392

  Fly   696 QPQSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLN 760
            |||:||||:||||.||||||||.|||||.||::|||||||:|||||||||||||||:||..||||
Mouse   393 QPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLN 457

  Fly   761 PQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKP 825
            |.|||||||.|:.|||||||||.:|||||||||||||.:|:||||||.::||||.|||||||.||
Mouse   458 PYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKP 522

  Fly   826 ITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSFGALVVHELKPGGASIPVTEENKREY 890
            |.|.|:|.|||:||:||.|:||::|:.:::.||.||:|:||.::.|||||.|.::|||||||:||
Mouse   523 IQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEY 587

  Fly   891 VKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHC 955
            |:||||:|||||||.|||||||||.||||.|||:|||::||||:|||:..||:|||::|||||||
Mouse   588 VRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHC 652

  Fly   956 TNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPT 1020
            ..::..|.||||.||::..|.|||||||||||:|||||||:||||||||.||||||||| .|..|
Mouse   653 VADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHL-IDANT 716

  Fly  1021 QNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAVE 1061
            .|||||||||||||:||||:|:.|.:||..|||||||||||
Mouse   717 DNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_523779.1	C2_Smurf-like	14..135	CDD:176028	76/122 (62%)
		PRP40	155..>283	CDD:227435	16/127 (13%)
		WW	169..198	CDD:459800	3/28 (11%)
		WW	514..546	CDD:197736	24/31 (77%)
		WW	562..594	CDD:197736	26/31 (84%)
		HECTc	702..1058	CDD:238033	259/355 (73%)
Smurf1	XP_006504947.1	C2_Smurf-like	14..138	CDD:176028	77/123 (63%)
		WW	236..267	CDD:197736	24/30 (80%)
		WW	307..339	CDD:197736	26/31 (84%)
		HECTc	399..754	CDD:238033	259/355 (73%)