DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and Herc3

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	NP_001348895.1	Gene:	Herc3 / 73998	MGIID:	1921248	Length:	1050	Species:	Mus musculus

Alignment Length:	412	Identity:	129/412 - (31%)
Similarity:	208/412 - (50%)	Gaps:	51/412 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   680 DLVGKLRALRT--ELQ-----------------TMQP---QSGHCRLEVSRNEIFEESYRLIMKM 722
            |...|.:.|:|  |||                 |::|   :|....|.|.||.:..::.|.:...
Mouse   658 DAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNHLVGDALRELSIH 722

  Fly   723 RAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSGVNPD 787
            ...|::|.|.|.|.||||:|.|||.:|:..||.:|:|||.||:|.|.:|.: .|..:....|  :
Mouse   723 SDIDLKKPLKVIFDGEEGVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSN-LLWFSDTCFV--E 784

  Fly   788 HLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISG 852
            | ::||.:|.|.|:|:::...:|..|....||:|||...:|.|::.:.|...|||..:|:.....
Mouse   785 H-NWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPSLEDLKELSPTEGRSLQELLDYPGED 848

  Fly   853 IIES---TFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGF 914
            |.|:   .|:|...|:|.:...:|.|||..:.|.::|::|:|..||||.|...:.:.:.|...||
Mouse   849 IEETFCLNFTVCRESYGVIEQKKLIPGGDRVAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGF 913

  Fly   915 CELIPSHLLRPFDERELELVIGGISSIDVND------WRNNTRLKHCTNETTQVLWFWQVVESYS 973
            .::....:|..|...||..::.|.|:.|..:      :|.:....|.|     |..||:....:.
Mouse   914 LKVCGGKVLELFQPAELRAMMVGNSNYDWEELEETAVYRGDYSSTHPT-----VKLFWETFHEFP 973

  Fly   974 SEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPY 1038
            .|.:.:.|.|:|||.|:|:.|..:||          ..|..|| ...:.||.||||:|.:|||.|
Mouse   974 LEKKKKFLLFLTGSDRIPIYGMASLQ----------IIIQSTA-TGEEYLPVAHTCYNLLDLPKY 1027

  Fly  1039 ETYQLLCDKLTQAVEETCGFAV 1060
            .:.:::..:||||::...||::
Mouse  1028 SSKEIMKARLTQALDNYEGFSL 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033	117/364 (32%)
		HECTc	726..1058	CDD:214523	112/340 (33%)
Herc3	NP_001348895.1	ATS1	2..331	CDD:227511
		RCC1	313..377	CDD:366085
		HECTc	702..1048	CDD:238033	118/365 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810