DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smurf and hace1

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_012818577.2	Gene:	hace1 / 734146	XenbaseID:	XB-GENE-5757512	Length:	1012	Species:	Xenopus tropicalis

Alignment Length:	421	Identity:	171/421 - (40%)
Similarity:	237/421 - (56%)	Gaps:	25/421 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   652 TTNPPHRIVPDLPQGLLEGADLLPKYRRDLVGKLRALRTE-----LQTMQPQSGHCR-------- 703
            |.||  :|:.|....|||..:|:.::...:..:....|.|     |...||.|....
Frog   595 TRNP--KIIFDHFHFLLECPELMSRFMHIIKAQPFKERCEWFYEHLLAGQPDSDMVHRPVNENDI 657

  Fly   704 LEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQY 768
            |.|.|:.||..|..::.|...:.:::.:.|:|.||||:.. ||.|||..:||.|::||.|.||..
Frog   658 LLVHRDSIFRSSCEVVFKSNCEKLKQGIAVRFHGEEGMGQ-GVVREWFDILSSEIINPDYALFTQ 721

  Fly   769 SRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKPITLGDIEG 833
            |.|. .|.|.|.:|.||||||:||.|.|..||:|::|...::..||..|||.:|..|:...|:..
Frog   722 SADG-TTFQPNSNSSVNPDHLNYFRFAGEILGLALYHRQLVNIYFTRSFYKHILGIPVNYQDVAS 785

  Fly   834 VDPDLHRSLTWMLESNISGI-IESTFSVENNSFGALVVHELKPGGASIPVTEENKREYVKLYVNY 897
            :||:..::|.|:|:::||.: :|.|||||.:.|||:....||||||||.||:|||.|||:|....
Frog   786 IDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGASILVTQENKAEYVQLVTEL 850

  Fly   898 RFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQV 962
            |..|.|:.|.....:||...||..|::.|||.||||::.|:..||||||..||..........||
Frog   851 RMTRAIQPQINGFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWMKNTEYTSGYERDDQV 915

  Fly   963 L-WFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKA 1026
            : |||:||:..:.|.|..||||||||||||..||..:.|.:|.   :.|||...|..|.. ||.:
Frog   916 IQWFWEVVQELTQEERVLLLQFVTGSSRVPHGGFAYIMGGSGL---QNFTIAAVAYTPNL-LPTS 976

  Fly  1027 HTCFNRIDLPPYETYQLLCDKLTQAVEETCG 1057
            .||.|.:.||.|.:.::|.|:|..|:.  ||
Frog   977 STCINMLKLPEYPSKEILKDRLLVALH--CG 1005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033	156/366 (43%)
		HECTc	726..1058	CDD:214523	149/334 (45%)
hace1	XP_012818577.2	PLN03192	<19..289	CDD:215625
		ANK repeat	134..163	CDD:293786
		ANKYR	<160..288	CDD:223738
		ANK repeat	165..196	CDD:293786
		ANK repeat	198..229	CDD:293786
		ANK repeat	231..262	CDD:293786
		ANK repeat	264..289	CDD:293786
		HECTc	657..1006	CDD:238033	156/357 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000080
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910