Protein Alignment Smurf and UBE3A

DIOPT Version :9

• Sequence 1: NP_001261061.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: NP_000453.2
• Gene: UBE3A / 7337
• HGNCID: 12496
• Length: 875
• Species: Homo sapiens
• Alignment Length: 382
• Identity: 119/382 - (31%)
• Similarity: 201/382 - (52%)
• Gaps: 38/382 - (9%)

  Fly   693 QTMQPQSGHCRLEVSRNEIFEES---YRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLL 754
            |.:.|   :.||:|.|:.|.:::   ..:|......|::|:|.|:|:||:|:|.|||::|:..|:
Human   517 QQLNP---YLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLV 578

  Fly   755 SREMLNPQYGLFQYSRDDHYT--LQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPF 817
            ..|:.||..|:|.|   |..|  ...||.|.   :....|..:|..||:|:::...||..|....
Human   579 VEEIFNPDIGMFTY---DESTKLFWFNPSSF---ETEGQFTLIGIVLGLAIYNNCILDVHFPMVV 637

  Fly   818 YKQLLNKPITLGDIEGVDPDLHRSLTWML--ESNISGIIESTFSV-ENNSFGALVVHELKPGGAS 879
            |::|:.|..|..|:....|.|::||..:|  |.|:...:..||.: :.:.||..::::||..|..
Human   638 YRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDK 702

  Fly   880 IPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPS-----HLLRPFDERELELVIGGIS 939
            ||:|.||::|:|.||.:|...:.:|:||.|.::|| .::.:     :|.||   .|:||:|.|..
Human   703 IPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGF-HMVTNESPLKYLFRP---EEIELLICGSR 763

  Fly   940 SIDVNDWRNNTRLK-HCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTG 1003
            ::|.......|... ..|.::..:..||::|.|::.|.:...|||.||:.|.|:.|...|:....
Human   764 NLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIA 828

  Fly  1004 AVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAV 1060
            ..||           .|:.||.:|||||.:.||.|.:.:.|.::|.:|:....||.:
Human   829 KNGP-----------DTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809
		WW	514..546	CDD:197736
		WW	562..594	CDD:197736
		HECTc	702..1058	CDD:238033	115/369 (31%)
		HECTc	726..1058	CDD:214523	109/342 (32%)
UBE3A	NP_000453.2	AZUL	29..83	CDD:406862
		HECTc	523..873	CDD:238033	116/370 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910