DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smurf and Ubr5

DIOPT Version :9

Sequence 1:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster
Sequence 2:	XP_006520242.1	Gene:	Ubr5 / 70790	MGIID:	1918040	Length:	2800	Species:	Mus musculus

Alignment Length:	1312	Identity:	248/1312 - (18%)
Similarity:	394/1312 - (30%)	Gaps:	463/1312 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 VGPSGDVRGPSEDDSSEDSLPEGWEERRTDNGRVYYVNHATKSTQWDRPRQPGVVGSSHATSPQQ 214
            :..|..|||  .|:..:|.:....||.....|.....:|..:..:.         |..:|.: :.
Mouse  1548 ISQSQPVRG--RDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEH---------GEENAEA-EG 1600

  Fly   215 RHNTHNGNSGDRQ---APAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHSTEILSSVGKENTSP 276
            .|:.|:.:..|.:   ..|..|.|.:.:|..|..:.|          .|.|....::.|.|..:.
Mouse  1601 HHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNAS----------GRRSVVTAATAGSEAGAS 1655

  Fly   277 TTPV--SATTTPGKKTSSSNSSSAGGRTLEQRP--TNEP---ATPTSSTTSASVRLHSNDNHVKT 334
            :.|.  |...:....:|.|:|||:....:||..  .:||   .|.:|....|:....|....|:.
Mouse  1656 SVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRN 1720

  Fly   335 PKHQTNGHAPPESTPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTSPST 399
            |:||......|.||.|........:..:..|...||..|..||...:|.      :|:..:|..|
Mouse  1721 PQHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAAL------EASNASSYLT 1779

  Fly   400 TTSPPRHSQSPPTPNISPPASVTPSANGNVHS--PNA---------------------------- 434
            :.|....:.|.....||....:.|..|..|:|  |.|
Mouse  1780 SASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVS 1844

  Fly   435 --NSTPAGSGGGSRSYTAATPG---------QRSQRRSSRQQGEESSTR----RRSSRGTRNGGT 484
              :||.|....||...:|..||         |.|.||......||:|.|    ||  |.|.....
Mouse  1845 VMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRR--RATLLSAR 1907

  Fly   485 SGGGGGGGSGQRYASAAIAAANQA---ARPFLDLPPGYEMRTTQQGQVYFYHIPTGVSTWHDPRI 546
            .|.....|....||.:.:.:.|..   ..|.||:.....:....|..:|:.......:|...|::
Mouse  1908 QGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQL 1972

  Fly   547 PR--------------------DFDT-QHLTL--------------------------------- 557
            .|                    |.|| |..||
Mouse  1973 ERKRTRELLELGIDNEDSEHENDDDTSQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPP 2037

  Fly   558 ---------------------------DAIGPLPSGWEQRKTASGR-VYFVDHNNRTTQFTDPRL 594
                                       |..|....|.......||: :..|..:....:....::
Mouse  2038 NPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSAGSGKCIVEVTMDRNCLEVLPTKM 2102

  Fly   595 S-----GSILQMIRR----GTVPPTSAANAGTPAPPSATPATPSAAAAVPPQATPASNATPTTLT 650
            |     .:::.|..|    |......|..|.:..|   .|:.|..||.:     .:|......||
Mouse  2103 SYAANLKNVMNMQNRQKKEGEEQSLLAEEADSSKP---GPSAPDVAAQL-----KSSLLAEIGLT 2159

  Fly   651 TTTNPPHRIVPDLPQ----GLLEGAD-LLPKYR--RDLVGKLRALRTELQTMQPQSGHCRLEVSR 708
            .:..||  :....||    |::...| ||.::|  .:|.|     |..::.:..:.|....|:..
Mouse  2160 ESEGPP--LTSFRPQCSFMGMVISHDMLLGRWRLSLELFG-----RVFMEDVGAEPGSILTELGG 2217

  Fly   709 NEIFEESYRLIM-KMRAKDMR--------------------------------------KRLMVK 734
            .|:.|..:|..| |:|.:..|                                      .|:.|.
Mouse  2218 FEVKESKFRREMEKLRNQQSRDLSLEVKVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVT 2282

  Fly   735 FKGEEGLDYGGVAREWLHLLS-------------------------------------------R 756
            ||.|.| :..||||.:...::                                           |
Mouse  2283 FKDEPG-EGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQRLRNRGERDRERERER 2346

  Fly   757 EM--------------------------------------------------------------- 758
            ||
Mouse  2347 EMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPDPLPAHRQALGERLYPRVQAMQ 2411

  Fly   759 -------------LNPQYGLFQYSRDDHYTLQIN------------------------------- 779
                         |:|...|...:.:|....:::
Mouse  2412 PAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLLDSSEKVQ 2476

  Fly   780 ----------------------------------------PDSGVNPD-HLSYFHFVGRTLGIAV 803
                                                    |..|.|.: .|:.|..:||.||:.:
Mouse  2477 ENRKRHGSSRSVVDMDLEDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCL 2541

  Fly   804 FHGHCLDGGFTTPFYKQLLNKPITLGDIEGVDPDLHRSLTWMLESNISGIIESTFSVENNSF--- 865
            ...............|.||.:.:...|....||.::.||..::.::.|...::.||..:.:|
Mouse  2542 LQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAID 2606

  Fly   866 ------GALVVHELKPGGASIPVTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLR 924
                  |..|  ||.|.|.:||||.:|..|||:.|..:|.:...||...|::||..:::|.:.|.
Mouse  2607 LCKEEGGGQV--ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLE 2669

  Fly   925 PFDERELELVIGGISSIDVNDWRNNTRLKHCTNETTQVL-----WFWQVVESYSSEMRARLLQFV 984
            .....:..|::.|...::|....:.|.....:.|..:.|     |||.:||..|...|..|:.|.
Mouse  2670 DLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFW 2734

  Fly   985 TGSSRVPL--QGFRALQGSTGAVGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDK 1047
            |.|..:|.  :||:.:..         .||....|   |:||.|:||.:|:.:|.|.:.|:|..|
Mouse  2735 TSSPSLPASEEGFQPMPS---------ITIRPPDD---QHLPTANTCISRLYVPLYSSKQILKQK 2787

  Fly  1048 LTQAVE-ETCGF 1058
            |..|:: :..||
Mouse  2788 LLLAIKTKNFGF 2799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028
		WW	169..198	CDD:278809	4/28 (14%)
		WW	514..546	CDD:197736	5/31 (16%)
		WW	562..594	CDD:197736	4/32 (13%)
		HECTc	702..1058	CDD:238033	106/602 (18%)
		HECTc	726..1058	CDD:214523	99/577 (17%)
Ubr5	XP_006520242.1	CUE_UBR5	184..230	CDD:270606
		ZnF_UBR1	1177..1244	CDD:197698
		PolyA	2391..2454	CDD:197769	4/62 (6%)
		HECTc	2469..2797	CDD:214523	81/341 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900