DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smurf and Herc4

DIOPT Version :9

Sequence 1:NP_001261061.1 Gene:Smurf / 36999 FlyBaseID:FBgn0029006 Length:1061 Species:Drosophila melanogaster
Sequence 2:NP_084390.1 Gene:Herc4 / 67345 MGIID:1914595 Length:1057 Species:Mus musculus


Alignment Length:444 Identity:133/444 - (29%)
Similarity:211/444 - (47%) Gaps:75/444 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   662 DLPQGLLEGADL---LPKYRRDLVGKLRALRTELQT-------MQPQSGH--------------- 701
            |:..|:.|.||:   :..|  ..|...:|..|.|||       |.....|               
Mouse   643 DVSHGVTELADIPVTICTY--PFVFDAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESV 705

  Fly   702 --CRLEVSRNE-IFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQY 763
              |.:.|.|.| |..::..::.|.:..|.:|.|.|.|.||:.:|.|||.:|:..|:.||:|:|:|
Mouse   706 NPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKY 770

  Fly   764 GLFQYSRDDH---YTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNKP 825
            |:|:|..|..   ::.:...||.:       ||.:|...|:|:::...:|..|....||:||.:.
Mouse   771 GMFRYYEDSRLIWFSDKTFEDSDL-------FHLIGVICGLAIYNFTIVDLHFPLALYKKLLKRK 828

  Fly   826 ITLGDIEGVDPDLHRSLTWMLESNISGIIES-----TFSVENNSFGALVVHELKPGGASIPVTEE 885
            .:|.|::.:.|.:.||:..:|:.....|.|:     |.:|||  |||..|.||...||...|..:
Mouse   829 PSLDDLKELMPAVGRSMQQLLDYPEDDIEETFCLNFTITVEN--FGATEVKELVLNGADTAVNRQ 891

  Fly   886 NKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRNNT 950
            |::|:|..||:|.|.:.:...|.|...||.::....:|..|...||:.::.|.::.|..:...||
Mouse   892 NRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNT 956

  Fly   951 RLK------HCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQ---GSTGAVG 1006
            ..|      |.|     :..||:|......|.:.:.|.|:|||.|:|:.|.::|:   .|||  |
Mouse   957 EYKGEYWADHPT-----IKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSLKLVIQSTG--G 1014

  Fly  1007 PRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETCGFAV 1060
            ...:            ||.:|||||.:|||.|...:.|..||.||::...||::
Mouse  1015 GESY------------LPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSL 1056

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmurfNP_001261061.1 C2_Smurf-like 14..135 CDD:176028
WW 169..198 CDD:278809
WW 514..546 CDD:197736
WW 562..594 CDD:197736
HECTc 702..1058 CDD:238033 117/373 (31%)
HECTc 726..1058 CDD:214523 111/348 (32%)
Herc4NP_084390.1 RCC1 1 1..51
RCC1 3..49 CDD:278826
RCC1 2 52..101
RCC1 52..99 CDD:278826
RCC1 3 102..154
RCC1 102..152 CDD:278826
RCC1 4 156..207
RCC1 157..205 CDD:278826
RCC1 5 208..259
RCC1 208..257 CDD:278826
RCC1 260..308 CDD:278826
RCC1 6 261..311
RCC1 7 313..366
RCC1 313..>343 CDD:278826
HECTc 709..1055 CDD:238033 117/373 (31%)
HECTc 735..1054 CDD:214523 110/346 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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